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  Gating transition of pentameric ligand-gated ion channels

Zhu, F., & Hummer, G. (2009). Gating transition of pentameric ligand-gated ion channels. Biophysical Journal (Annual Meeting Abstracts), 97(9), 2456-2463. doi:10.1016/j.bpj.2009.08.020.

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 Urheber:
Zhu, Fangqiang1, Autor
Hummer, Gerhard1, Autor           
Affiliations:
1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, USA, ou_persistent22              

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Schlagwörter: Bacterial Proteins, Biophysics, Cell Membrane, Computer Simulation, Elasticity, Electrophysiology, Ion Channel Gating, Ion Channels, Ligands, Membrane Proteins, Models, Statistical, Molecular Conformation, Protein Binding, Protein Conformation
 Zusammenfassung: Pentameric ligand-gated ion channels are an important family of membrane proteins and play key roles in physiological processes, including signal transduction at chemical synapses. Here, we study the conformational changes associated with the opening and closing of the channel pore. Based on recent crystal structures of two prokaryotic members of the family in open and closed states, respectively, mixed elastic network models are constructed for the transmembrane domain. To explore the conformational changes in the gating transition, a coarse-grained transition path is computed that smoothly connects the closed and open conformations of the channel. We find that the conformational transition involves no major rotations of the transmembrane helices, and is instead characterized by a concerted tilting of helices M2 and M3. In addition, helix M2 changes its bending state, which results in an early closure of the pore during the open-to-closed transition.

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Sprache(n): eng - English
 Datum: 2009-07-022009-08-312009-11-04
 Publikationsstatus: Erschienen
 Seiten: 8
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.bpj.2009.08.020
BibTex Citekey: zhu_gating_2009
 Art des Abschluß: -

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Titel: Biophysical Journal (Annual Meeting Abstracts)
  Andere : Biophys. J. (Annual Meeting Abstracts)
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Bethesda, MD : Biophysical Society
Seiten: - Band / Heft: 97 (9) Artikelnummer: - Start- / Endseite: 2456 - 2463 Identifikator: ISSN: 0006-3495
CoNE: https://pure.mpg.de/cone/journals/resource/954925385117_1