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  Effect of Gene SFU1 on Riboflavin Synthesis in Flavinogenic Yeast Candida famata

Petrovska, Y., Lyzak, O., Dmytruk, K., & Sibirny, A. (2020). Effect of Gene SFU1 on Riboflavin Synthesis in Flavinogenic Yeast Candida famata. Cytology and Genetics, 54(5), 408-412. doi:10.3103/S0095452720050060.

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Genre: Journal Article

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 Creators:
Petrovska, Y.1, Author
Lyzak, O.2, Author              
Dmytruk, K.1, Author
Sibirny, A.1, Author
Affiliations:
1external, ou_persistent22              
2Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565176              

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Free keywords: CONSTRUCTIONGenetics & Heredity; riboflavin; Candida famata; SFU1; yeast;
 Abstract: Riboflavin or vitamin B-2 is a necessary component for all living organisms since it is the precursor of flavin coenzymes FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide), which are involved in numerous enzymatic reactions. Flavinogenic yeastCandida famataoverproduces riboflavin under iron starvation; however, regulation of this process is poorly understood. Regulatory gene SEF1 encoding the transcription activator has been identified. Its deletion blocks yeast's ability to overproduce riboflavin under iron starvation. It is known that, in the pathogenic flavinogenic yeastC. albicans, Sfu1 (GATA-type transcription factor) represses SEF1. It is demonstrated in this study that deletion of the SEF1 gene in wild typeC. famataleads to overproduction of riboflavin.

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Language(s): eng - English
 Dates: 2020-10
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000576813900005
DOI: 10.3103/S0095452720050060
 Degree: -

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Title: Cytology and Genetics
Source Genre: Journal
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Publ. Info: 18 WEST 27TH ST, NEW YORK, NY 10001 USA : Allerton Press
Pages: - Volume / Issue: 54 (5) Sequence Number: - Start / End Page: 408 - 412 Identifier: ISSN: 0095-4527