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  Intravascular BOLD signal characterization of balanced SSFP experiments in human blood at high to ultrahigh fields

Pérez-Rodas, M., Pohmann, R., Scheffler, K., & Heule, R. (2021). Intravascular BOLD signal characterization of balanced SSFP experiments in human blood at high to ultrahigh fields. Magnetic Resonance in Medicine, 85(4), 2055-2068. doi:10.1002/mrm.28575.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-54C4-D Version Permalink: http://hdl.handle.net/21.11116/0000-0007-9FDF-C
Genre: Journal Article

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Pérez-Rodas, M1, 2, Author              
Pohmann, R1, 2, Author              
Scheffler, K1, 2, Author              
Heule, R1, 2, Author              
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Purpose: To investigate the intravascular contribution to the overall balanced SSFP (bSSFP) BOLD effect in human blood at high to ultrahigh field strengths (3 T, 9.4 T, and 14.1 T). Methods: Venous blood prepared at two different oxygenation levels (deoxygenated: Y ≈ 71%, oxygenated: Y ≈ 94%) was measured with phase-cycled bSSFP for varying TRs/flip angles at 3 T, 9.4 T, and 14.1 T. The oxygen sensitivity was analyzed by intrinsic MIRACLE (motion-insensitive rapid configuration relaxometry)-R2 estimation and passband signal differences. The intravascular BOLD-related signal change was extracted from the measured data for microvasculature and macrovasculature, and compared with the extravascular contribution obtained by Monte Carlo simulations. Results: The MIRACLE-R2 values showed a characteristic increase with longer TRs in deoxygenated blood, corroborating that SE-R2 data cannot be used to assess the intravascular bSSFP BOLD effect. Passband bSSFP signal differences measured at optimal flip angles of 30° at 3 T and 20° at 9.4 T/14.1 T revealed considerable relative intravascular contributions of 95%/70% at 3 T, 74%/43% at 9.4 T, 66%/46% at 14.1 T for TR = 5 ms, and 90%/65% at 3 T, 36%/27% at 9.4 T, 13%/15% at 14.1 T for TR = 10 ms in macrovascular/microvascular regimes. Conclusion: The results indicate that intravascular effects have to be considered to better understand the origin of bSSFP BOLD contrast in functional MRI experiments, especially at short TRs. The MIRACLE-R2 method demonstrated the ability to quantify the apparent decrease in R2 due to rapid RF refocusing.

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 Dates: 2020-112021-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.28575
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 85 (4) Sequence Number: - Start / End Page: 2055 - 2068 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149