English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  How to approach flow chemistry

Guidi, M., Seeberger, P. H., & Gilmore, K. (2020). How to approach flow chemistry. Chemical Society Reviews, 49(24), 8910-8932. doi:10.1039/C9CS00832B.

Item is

Files

show Files
hide Files
:
Article.pdf (Publisher version), 10MB
Name:
Article.pdf
Description:
-
OA-Status:
Hybrid
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-

Locators

show

Creators

show
hide
 Creators:
Guidi, Mara1, Author           
Seeberger, Peter H.2, Author           
Gilmore, Kerry1, Author           
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

Content

show
hide
Free keywords: -
 Abstract: Flow chemistry is a widely explored technology whose intrinsic features both facilitate and provide reproducible access to a broad range of chemical processes that are otherwise inefficient or problematic. At its core, a flow chemistry module is a stable set of conditions – traditionally thought of as an externally applied means of activation/control (e.g. heat or light) – through which reagents are passed. In an attempt to simplify the teaching and dissemination of this field, we envisioned that the key advantages of the technique, such as reproducibility and the correlation between reaction time and position within the reactor, allow for the redefinition of a flow module to a more synthetically relevant one based on the overall induced effect. We suggest a rethinking of the approach to flow modules, distributing them in two subclasses: transformers and generators, which can be described respectively as a set of conditions for either performing a specific transformation or for generating a reactive intermediate. The chemistry achieved by transformers and generators is (ideally) independent of the substrate introduced, meaning that they must be robust to small adjustments necessary for the adaptation to different starting materials and reagents while ensuring the same chemical outcome. These redefined modules can be used for single-step reactions or in multistep processes, where modules can be connected to each other in reconfigurable combinations to create chemical assembly systems (CAS) targeting compounds and libraries sharing structural cores. With this tutorial review, we provide a guide to the overall approach to flow chemistry, discussing the key parameters for the design of transformers and generators as well as the development of chemical assembly systems.

Details

show
hide
Language(s): eng - English
 Dates: 2020-11-032020
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1039/C9CS00832B
BibTex Citekey: C9CS00832B
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Chemical Society Reviews
  Other : Chem. Soc. Rev.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Royal Society of Chemistry, etc.
Pages: - Volume / Issue: 49 (24) Sequence Number: - Start / End Page: 8910 - 8932 Identifier: ISSN: 0306-0012