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  Localized singlet-filtered MRS in vivo

Mamone, S., Schmidt, A. B., Schwaderlapp, N., Lange, T., Elverfeldt, D. v., Hennig, J., et al. (2021). Localized singlet-filtered MRS in vivo. NMR in Biomedicine, 34(1): e4400. doi:10.1002/nbm.4400.

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 Creators:
Mamone, S.1, Author              
Schmidt, A. B., Author
Schwaderlapp, N., Author
Lange, T., Author
Elverfeldt, D. von, Author
Hennig, J., Author
Glöggler, S.1, Author              
Affiliations:
1Research Group of NMR Signal Enhancement, MPI for Biophysical Chemistry, Max Planck Society, ou_2396691              

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Free keywords: brain, in vivo, magnetic resonance, metabolites, MRS, singlet state, spectroscopy
 Abstract: MR is a prominent technology to investigate diseases, with millions of clinical proce- dures performed every year. Metabolic dysfunction is one common aspect associated with many diseases. Thus, understanding and monitoring metabolic changes is essen- tial to develop cures for many illnesses, including for example cancer and neu- rodegeneration. MR methodologies are especially suited to study endogenous metabolites and processes within an organism in vivo, which has led to many insights about physiological functions. Advancing metabolic MR techniques is therefore key to further understand physiological processes. Here, we introduce an approach based on nuclear spin singlet states to specifically filter metabolic signals and particularly show that singlet-filtered glutamate can be observed distinctly in the hippocampus of a living mouse in vivo. This development opens opportunities to make use of the sin- glet spin phenomenon in vivo and besides its use as a filter to provide scope for new contrast agents.

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Language(s): eng - English
 Dates: 2020-09-012021-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/nbm.4400
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Title: NMR in Biomedicine
Source Genre: Journal
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Pages: 10 Volume / Issue: 34 (1) Sequence Number: e4400 Start / End Page: - Identifier: -