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  How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics

Fonkeu, Y., Kraynyukova, N., Hafner, A., Kochen, L., Sartori, F., Schuman, E. M., et al. (2020). How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics. Neuron, 103(6), 1109-1122. doi:10.1016/j.neuron.2019.06.022.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-A89E-A Version Permalink: https://hdl.handle.net/21.11116/0000-000A-5181-8
Genre: Journal Article

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1-s2.0-S0896627319305720-main.pdf (Publisher version), 4MB
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Copyright Date:
2019
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Under an Elsevier user license
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https://www.elsevier.com/about/policies/open-access-licenses/elsevier-user-license

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 Creators:
Fonkeu, Y.1, Author
Kraynyukova, N.1, Author
Hafner, A.S.1, Author
Kochen, L.1, Author
Sartori, F.1, Author
Schuman, E. M.1, Author           
Tchumatchenko, T.1, Author
Affiliations:
1Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society, ou_2461710              

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 Abstract: In this issue ofNeuron,Fonkeu et al. (2019)present a mathematical model of mRNA and protein synthesis,degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distributionand temporal dynamics of proteins along dendrites. The authors use the model to account forin situimagingdata of CaMKII⍺mRNA and protein in hippocampal neurons.

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Language(s): eng - English
 Dates: 2018-09-122019-06-222019-07-232020-09-25
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.neuron.2019.06.022
PMID: 31350097
 Degree: -

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Project name : ERC-AdG NeuroRibo
Grant ID : 743216
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : SFB 1080: Molecular and Cellular Mechanisms of Neural Homeostasis (Subproject B01)
Grant ID : 221828878
Funding program : Sonderforschungsbereiche (SFB)
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 103 (6) Sequence Number: - Start / End Page: 1109 - 1122 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565