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  Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia

Andreu-Bernabeu, A., Diaz-Caneja, C. M., Costas, J., De Hoyos, L., Stella, C., Gurriaran, X., et al. (2022). Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia. Nature Communications, 13: 51. doi:10.1038/s41467-021-27598-6.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-5D01-0 Version Permalink: https://hdl.handle.net/21.11116/0000-000B-58A5-8
Genre: Journal Article

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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 Creators:
Andreu-Bernabeu, Alvaro, Author
Diaz-Caneja, Covadonga Martinez, Author
Costas, Javier, Author
De Hoyos, Lucía1, Author           
Stella, Carol, Author
Gurriaran, Xaquin, Author
Alloza, Clara, Author
Fañanás, Lourdes, Author
Bobes, Julio, Author
Gonzalez-Pinto, Ana, Author
Crespo-Facorro, Benedicto, Author
Martorell, Lourdes, Author
Vilella, Elisabet, Author
Muntane, Gerard, Author
Nacher, Juan, Author
Molto, Maria Dolores, Author
Aguilar, Eduardo Jesus, Author
Parellada, Mara, Author
Arango, Celso, Author
González-Peñas, Javier, Author
Affiliations:
1Hospital General Universitario Gregorio Marañón, Madrid, Spain, ou_persistent22              

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 Abstract: Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia.

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Language(s): eng - English
 Dates: 2022-01-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-27598-6
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 13 Sequence Number: 51 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723