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  Propagation of BOLD activity reveals task-dependent directed interactions across human visual cortex

Gravel, N., Renken, R. J., Harvey, B. M., Deco, G., Cornelissen, F. W., & Gilson, M. (2020). Propagation of BOLD activity reveals task-dependent directed interactions across human visual cortex. Cerebral Cortex, 30(11), 5899-5914. doi:10.1093/cercor/bhaa165.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-5D25-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000D-CA91-B
Genre: Journal Article

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Locator:
https://academic.oup.com/cercor/article/30/11/5899/5861609 (Publisher version)
Description:
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OA-Status:
Green

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 Creators:
Gravel, Nicolás1, 2, Author
Renken, Remco J.2, 3, Author
Harvey, Ben M.4, Author
Deco, Gustavo5, 6, 7, 8, Author           
Cornelissen, Frans W.2, Author
Gilson, Matthieu5, Author
Affiliations:
1Neural Dynamics of Visual Cognition Group, Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
2Laboratory of Experimental Ophthalmology, University Medical Center Groningen, the Netherlands, ou_persistent22              
3Cognitive Neuroscience Center (CNC), University Medical Center Groningen, the Netherlands, ou_persistent22              
4Department of Experimental Psychology, Helmholtz Institute, Utrecht University, the Netherlands, ou_persistent22              
5Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain, ou_persistent22              
7Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
8School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: BOLD activity propagation; Functional neuroanatomy; Network connectivity modeling; Resting state; Visual cortical maps
 Abstract: It has recently been shown that large-scale propagation of blood-oxygen-level-dependent (BOLD) activity is constrained by anatomical connections and reflects transitions between behavioral states. It remains to be seen, however, if the propagation of BOLD activity can also relate to the brain’s anatomical structure at a more local scale. Here, we hypothesized that BOLD propagation reflects structured neuronal activity across early visual field maps. To explore this hypothesis, we characterize the propagation of BOLD activity across V1, V2, and V3 using a modeling approach that aims to disentangle the contributions of local activity and directed interactions in shaping BOLD propagation. It does so by estimating the effective connectivity (EC) and the excitability of a noise-diffusion network to reproduce the spatiotemporal covariance structure of the data. We apply our approach to 7T fMRI recordings acquired during resting state (RS) and visual field mapping (VFM). Our results reveal different EC interactions and changes in cortical excitability in RS and VFM, and point to a reconfiguration of feedforward and feedback interactions across the visual system. We conclude that the propagation of BOLD activity has functional relevance, as it reveals directed interactions and changes in cortical excitability in a task-dependent manner.

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Language(s): eng - English
 Dates: 2020-03-132020-03-132020-05-022020-06-242020-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhaa165
PMID: 32577717
 Degree: -

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Project name : -
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Funding organization : National Commission for Scientific and Technological Research (BECAS CHILE)
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Grant ID : -
Funding program : -
Funding organization : Graduate School for Medical Sciences (GSMS)
Project name : -
Grant ID : -
Funding program : -
Funding organization : University Medical Center Groningen (UMCG)
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Grant ID : 433-09-233; 452-17-012
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
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Grant ID : #IF/01405/2014
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Funding organization : Portuguese Foundation for Science and Technology
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Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Project
Project name : -
Grant ID : 720270; 785907
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : -
Funding program : (2017 SGR 1545)
Funding organization : Catalan Agencia de Gestión de Ayudas Universitarias

Source 1

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 30 (11) Sequence Number: - Start / End Page: 5899 - 5914 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440