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  Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging

Mohammadi, S., & Callaghan, M. F. (2020). Towards in vivo g-ratio mapping using MRI: Unifying myelin and diffusion imaging. Journal of Neuroscience Methods, 108990. doi:10.1016/j.jneumeth.2020.108990.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-5E09-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-5E0A-6
Genre: Journal Article

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 Creators:
Mohammadi, Siawoosh1, 2, Author              
Callaghan, Martina F.3, Author
Affiliations:
1Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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Free keywords: g-ratio; Diffusion MRI; Magnetization transfer imaging; Myelin water imaging; Multi-parameter mapping; In-vivo histology using MRI; Biophysical modelling; Myelin, axon, and fiber volume fractions
 Abstract: Background The g-ratio, quantifying the comparative thickness of the myelin sheath encasing an axon, is a geometrical invariant that has high functional relevance because of its importance in determining neuronal conduction velocity. Advances in MRI data acquisition and signal modelling have put in vivo mapping of the g-ratio, across the entire white matter, within our reach. This capacity would greatly increase our knowledge of the nervous system: how it functions, and how it is impacted by disease. New method This is the second review on the topic of g-ratio mapping using MRI. Results This review summarizes the most recent developments in the field, while also providing methodological background pertinent to aggregate g-ratio weighted mapping, and discussing pitfalls associated with these approaches. Comparison with existing methods Using simulations based on recently published data, this review reveals caveats to the state-of-the-art calibration methods that have been used for in vivo g-ratio mapping. It highlights the need to estimate both the slope and offset of the relationship between these MRI-based markers and the true myelin volume fraction if we are really to achieve the goal of precise, high sensitivity g-ratio mapping in vivo. Other challenges discussed in this review further evidence the need for gold standard measurements of human brain tissue from ex vivo histology. Conclusions We conclude that the quest to find the most appropriate MRI biomarkers to enable in vivo g-ratio mapping is ongoing, with the full potential of many novel techniques yet to be investigated.

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Language(s): eng - English
 Dates: 2020-09-212020-05-212020-10-202020-10-28
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.jneumeth.2020.108990
Other: online ahead of print
PMID: 33129894
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Project name : -
Grant ID : AL 1156/2‐1; GE 2967/1‐1; MO 2397/5‐1; MO 2249/3–1
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Funding organization : German Research Foundation
Project name : -
Grant ID : MO 2397/4‐1
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Funding organization : Emmy Noether Stipend
Project name : -
Grant ID : 01fmthh2017
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Funding organization : Forschungszentrum Medizintechnik Hamburg
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Grant ID : 01EW1711A and B
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Funding organization : Bundesministerium für Bildung und Forschung
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Grant ID : MR/R000050/1
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Funding organization : Medical Research Council
Project name : -
Grant ID : 203147/Z/16/Z
Funding program : -
Funding organization : Wellcome Centre for Human Neuroimaging

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Title: Journal of Neuroscience Methods
  Other : J. Neurosci. Meth.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: - Sequence Number: 108990 Start / End Page: - Identifier: ISSN: 0165-0270
CoNE: https://pure.mpg.de/cone/journals/resource/954925480594