English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Subthalamic beta oscillations correlate with dopaminergic degeneration in experimental parkinsonism

Haumesser, J. K., Beck, M. H., Pellegrini, F., Kühn, J., Neumann, W.-J., Altschüler, J., et al. (2021). Subthalamic beta oscillations correlate with dopaminergic degeneration in experimental parkinsonism. Experimental Neurology, 335: 113513. doi:10.1016/j.expneurol.2020.113513.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0007-5E27-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-5E2A-2
Genre: Journal Article

Files

show Files
hide Files
:
Haumesser_2021.pdf (Publisher version), 4MB
Name:
Haumesser_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Haumesser, Jens K.1, Author
Beck, Maximilian H.1, Author
Pellegrini, Franziska1, Author
Kühn, Johanna1, Author
Neumann, Wolf-Julian1, Author
Altschüler, Jennifer1, Author
Harnack, Daniel1, 2, Author
Kupsch, Andreas3, Author
Nikulin, Vadim V.4, Author              
Kühn, Andrea A.1, 5, Author
van Riesen, Christoph1, 5, 6, 7, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Neurologische Rehabilitationsklinik, Beelitz, Germany, ou_persistent22              
3Clinic of Neurology and Stereotactic Neurosurgery, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
4Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
5German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
6Berlin Institute of Health (BIH), Germany, ou_persistent22              
7Department of Cognitive Neurology, University Medical Center, Göttingen, Germany, ou_persistent22              

Content

show
hide
Free keywords: Parkinson's disease; Beta oscillations; Neurodegeneration; Basal ganglia
 Abstract: Excessive beta activity has been shown in local field potential recordings from the cortico-basal ganglia loop of Parkinson's disease patients and in its various animal models. Recent evidence suggests that enhanced beta oscillations may play a central role in the pathophysiology of the disorder and that beta activity may be directly linked to the motor impairment. However, the temporal evolution of exaggerated beta oscillations during the ongoing dopaminergic neurodegeneration and its relation to the motor impairment and histological changes are still unknown. We investigated motor behavioral, in-vivo electrophysiological (subthalamic nucleus, motor cortex) and histological changes (striatum, substantia nigra compacta) 2, 5, 10 and 20–30 days after a 6-hydroxydopamine injection into the medial forebrain bundle in Wistar rats. We found strong correlations between subthalamic beta power and motor impairment. No correlation was found for beta power in the primary motor cortex. Only subthalamic but not cortical beta power was strongly correlated with the histological markers of the dopaminergic neurodegeneration. Significantly increased subthalamic beta oscillations could be detected before this increase was found in primary motor cortex. At the latest observation time point, a significantly higher percentage of long beta bursts was found. Our study is the first to show a strong relation between subthalamic beta power and the dopaminergic neurodegeneration. Thus, we provide additional evidence for an important pathophysiological role of subthalamic beta oscillations and prolonged beta bursts in Parkinson's disease.

Details

show
hide
Language(s): eng - English
 Dates: 2020-10-062020-07-232020-10-202020-10-242021-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.expneurol.2020.113513
Other: online ahead of print
PMID: 33148526
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : GE 2629/1-1
Funding program : -
Funding organization : German Research Foundation

Source 1

show
hide
Title: Experimental Neurology
  Other : Exp. Neurol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Diego, CA : Academic Press
Pages: - Volume / Issue: 335 Sequence Number: 113513 Start / End Page: - Identifier: ISSN: 0014-4886
CoNE: https://pure.mpg.de/cone/journals/resource/991042743109584