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  Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals

Hahn, G., Zamora-López, G., Uhrig, L., Tagliazucchi, E., Laufs, H., Mantini, D., et al. (2021). Signature of consciousness in brain-wide synchronization patterns of monkey and human fMRI signals. NeuroImage, 226: 117470. doi:10.1016/j.neuroimage.2020.117470.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-62A7-E Version Permalink: https://hdl.handle.net/21.11116/0000-000D-F2A2-A
Genre: Journal Article

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 Creators:
Hahn, Gerald1, Author
Zamora-López, Gorka1, Author
Uhrig, Lynn2, 3, Author
Tagliazucchi, Enzo4, 5, 6, 7, Author
Laufs, Helmut5, 8, Author
Mantini, Dante9, 10, Author
Kringelbach, Morten11, 12, 13, Author
Jarraya, Bechir2, 3, 14, 15, Author
Deco, Gustavo1, 16, 17, 18, Author           
Affiliations:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Neurospin, French Alternative Energies and Atomic Energy Commission (CEA), Gif-sur-Yvette, France, ou_persistent22              
3Cognitive Neuroimaging Unit, Neurospin Center, Institut national de la santé et de la recherche médicale, Paris, France, ou_persistent22              
4Department of Psychology, Christian Albrecht University Kiel, Germany, ou_persistent22              
5Brain Imaging Center (BIC), Goethe University, Frankfurt, Germany, ou_persistent22              
6Department of Physics, University of Buenos Aires, Argentina, ou_persistent22              
7National Scientific and Technical Research Council (CONICET), University of Buenos Aires, Argentina, ou_persistent22              
8Department of Neurology, Christian Albrecht University Kiel, Germany, ou_persistent22              
9Research Center for Motor Control and Neuroplasticity, Katholieke Universiteit Leuven, Belgium, ou_persistent22              
10Brain Imaging and Neural Dynamics Research Group, Scientific Institute for Research, Hospitalization and Health Care (IRCCS), Hospital San Camillo, Venice, Italy, ou_persistent22              
11Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
12Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
13Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
14University of Versailles Saint-Quentin-en-Yvelines, France, ou_persistent22              
15Neuromodulation Unit, Foch Hospital, Suresnes, France, ou_persistent22              
16Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
17Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
18School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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 Abstract: During the sleep-wake cycle, the brain undergoes profound dynamical changes, which are manifested subjectively as transitions between conscious experience and unconsciousness. Yet, neurophysiological signatures that can objectively distinguish different consciousness states based are scarce. Here, we show that differences in the level of brain-wide signals can reliably distinguish different stages of sleep and anesthesia from the awake state in human and monkey resting state data. Moreover, a whole-brain computational model can faithfully reproduce changes in global synchronization and other metrics such as the structure-function relationship, integration and segregation across vigilance states. We demonstrate that the awake brain is close to a Hopf bifurcation, which naturally coincides with the emergence of globally correlated fMRI signals. Furthermore, simulating lesions of individual brain areas highlight the importance of connectivity hubs in the posterior brain and subcortical structures in maintaining the model in the awake state, as predicted by graph-theoretical analyses of structural data.

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Language(s): eng - English
 Dates: 2020-11-012021-02-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.117470
Other: epub 2020
PMID: 33137478
 Degree: -

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Project name : Horizon 2020
Grant ID : 720270; 785907; 661583
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : 01 EV 0703
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)
Project name : -
Grant ID : 615539
Funding program : -
Funding organization : European Research Council (ERC)
Project name : -
Grant ID : DNRF117
Funding program : -
Funding organization : Danish National Research Foundation (DNRF)
Project name : -
Grant ID : KN 588/7–1
Funding program : -
Funding organization : German Research Council (DFG)
Project name : -
Grant ID : PID2019-105772GB-I00 /AEI/10.13039/501100011033
Funding program : (2017 SGR 1545)
Funding organization : Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI), and by the Catalan AGAUR program

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 226 Sequence Number: 117470 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166