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  Bisacylphosphane oxides as photo-latent cytotoxic agents and potential photo-latent anticancer drugs

Beil, A., Steudel, F. A., Braeuchle, C., Grutzmacher, H., & Möckl, L. (2019). Bisacylphosphane oxides as photo-latent cytotoxic agents and potential photo-latent anticancer drugs. Scientific Reports, 9: 6003. doi:10.1038/s41598-019-42026-y.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-6811-1 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-6812-0
Genre: Journal Article

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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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 Creators:
Beil, Andreas1, Author
Steudel, Friederike A.1, Author
Braeuchle, Christoph2, Author
Grutzmacher, Hansjorg1, Author
Möckl, Leonhard2, 3, 4, Author           
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1external, ou_persistent22              
2Ludwig-Maximilians-Universität München, ou_persistent22              
3External Organizations, ou_persistent22              
4Stanford University, ou_persistent22              

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 Abstract: Bisacylphosphane oxides (BAPOs) are established as photoinitiators for industrial applications. Light irradiation leads to their photolysis, producing radicals. Radical species induce oxidative stress in cells and may cause cell death. Hence, BAPOs may be suitable as photolatent cytotoxic agents, but such applications have not been investigated yet. Herein, we describe for the first time a potential use of BAPOs as drugs for photolatent therapy. We show that treatment of the breast cancer cell lines MCF-7 and MDA-MB-231 and of breast epithelial cells MCF-10A with BAPOs and UV irradiation induces apoptosis. Cells just subjected to BAPOs or UV irradiation alone are not affected. The induction of apoptosis depend on the BAPO and the irradiation dose. We proved that radicals are the active species since cells are rescued by an antioxidant. Finally, an optimized BAPO-derivative was designed which enters the cells more efficiently and thus leads to stronger effects at lower doses.

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Language(s): eng - English
 Dates: 2019-04-12
 Publication Status: Published online
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 Identifiers: ISI: 000464342700028
DOI: 10.1038/s41598-019-42026-y
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Title: Scientific Reports
Source Genre: Journal
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Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 9 Sequence Number: 6003 Start / End Page: - Identifier: ISSN: 2045-2322