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  In situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors

Zeis, P., Lian, M., Fan, X., Herman, J. S., Hernandez, D. C., Gentek, R., et al. (2020). In situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors. Immunity, 53, 775-792. doi:10.1016/j.immuni.2020.09.002.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-638C-C Version Permalink: http://hdl.handle.net/21.11116/0000-0007-638D-B
Genre: Journal Article

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10.1016_j.immuni.2020.09.002.pdf (Publisher version), 12MB
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 Creators:
Zeis, Patrice1, Author
Lian, Mi2, Author
Fan, Xiying2, Author
Herman, Josip S1, Author
Hernandez, Daniela C2, Author
Gentek, Rebecca2, Author
Elias, Shlomo2, Author
Symowski, Cornelia2, Author
Knöpper, Konrad2, Author
Peltokangas, Nina1, Author
Friedrich, Christin2, Author
Doucet-Ladeveze, Remi2, Author
Kabat, Agnieszka M1, Author
Locksley, Richard M2, Author
Voehringer, David2, Author
Bajenoff, Marc2, Author
Rudensky, Alexander Y2, Author
Romagnani, Chiara2, Author
Grün, Dominic1, Author              
Gasteiger, Georg2, Author
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243642              
2External Organizations, ou_persistent22              

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Free keywords: ILC2; ILCP; Innate lymphoid cells (ILC); Nippostrongylus Brasiliensis; bone marrow; immune system development; progenitors; single cell atlas; single-cell RNA-seq; tissue immunity
 Abstract: Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within tissues. We generated a single cell atlas of lung ILC2s and found that Il18r1+ ILCs comprise circulating and tissue-resident ILC progenitors (ILCP) and effector-cells with heterogeneous expression of the transcription factors Tcf7 and Zbtb16, and CD103. Our analyses revealed a continuous differentiation trajectory from Il18r1+ ST2- ILCPs to Il18r- ST2+ ILC2s, which was experimentally validated. Upon helminth infection, recruited and BM-derived cells generated the entire spectrum of ILC2s in parabiotic and shield chimeric mice, consistent with their potential role in the renewal of tissue ILC2s. Our findings identify local ILCPs and reveal ILCP in situ differentiation and tissue adaptation as a mechanism of ILC maintenance and phenotypic diversification. Local niches, rather than progenitor origin, or the developmental window during ontogeny, may dominantly imprint ILC phenotypes in adult tissues.

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Language(s): eng - English
 Dates: 2020-10-13
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.immuni.2020.09.002
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Title: Immunity
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 53 Sequence Number: - Start / End Page: 775 - 792 Identifier: ISSN: 1074-7613
CoNE: https://pure.mpg.de/cone/journals/resource/954925604783