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  Modulation of premotor cortex response to sequence motor learning during escitalopram intake

Molloy, E., Mueller, K., Beinhölzl, N., Blöchl, M., Piecha, F. A., Pampel, A., et al. (2020). Modulation of premotor cortex response to sequence motor learning during escitalopram intake. Journal of Cerebral Blood Flow and Metabolism. doi:10.1177/0271678X20965161.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-6748-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-6749-4
Genre: Journal Article

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 Creators:
Molloy, Eoin1, 2, 3, Author              
Mueller, Karsten4, Author              
Beinhölzl, Nathalie1, 2, Author              
Blöchl, Maria2, 3, 5, Author              
Piecha, Fabian A.1, 2, Author
Pampel, André4, Author              
Steele, Christopher6, Author              
Scharrer, Ulrike1, 2, Author
Zheleva, Gergana1, 2, Author
Regenthal, Ralf7, Author
Sehm, Bernhard2, Author              
Nikulin, Vadim V.2, 8, Author              
Möller, Harald E.4, Author              
Villringer, Arno2, 9, 10, Author              
Sacher, Julia1, 2, 9, Author              
Affiliations:
1Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Department of Psychology, Münster University, Germany, ou_persistent22              
6Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
7Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig, Germany, ou_persistent22              
8Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Functional magnetic resonance imaging; Neural plasticity; Post-stroke motor dysfunction; Selective serotonin reuptake inhibitors; Sequential motor learning
 Abstract: The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging in a double-blind, randomized controlled study to assess whether 20 mg escitalopram improves sequence-specific motor performance and modulates cortical motor response in 64 healthy female participants. We found decreased left premotor cortex responses during sequence-specific learning performance comparing single dose and steady escitalopram state. Escitalopram plasma levels negatively correlated with the premotor cortex response. We did not find evidence in support of improved motor performance after a week of escitalopram intake. These findings do not support the conclusion that one week escitalopram intake increases motor performance but could reflect early adaptive plasticity with improved neural processing underlying similar task performance when steady peripheral escitalopram levels are reached.

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Language(s): eng - English
 Dates: 2020-05-282020-09-042020-11-04
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X20965161
Other: online ahead of print
PMID: 33148103
 Degree: -

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202