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  Modulation of premotor cortex response to sequence motor learning during escitalopram intake

Molloy, E., Mueller, K., Beinhölzl, N., Blöchl, M., Piecha, F. A., Pampel, A., et al. (2021). Modulation of premotor cortex response to sequence motor learning during escitalopram intake. Journal of Cerebral Blood Flow and Metabolism, 41(6), 1449-1462. doi:10.1177/0271678X20965161.

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 Creators:
Molloy, Eoin1, 2, 3, Author           
Mueller, Karsten4, 5, Author           
Beinhölzl, Nathalie1, 2, Author           
Blöchl, Maria2, 3, 6, Author           
Piecha, Fabian A.1, 2, Author
Pampel, André4, Author           
Steele, Christopher7, Author           
Scharrer, Ulrike1, 2, Author
Zheleva, Gergana1, 2, Author
Regenthal, Ralf8, Author
Sehm, Bernhard2, Author           
Nikulin, Vadim V.2, 9, Author           
Möller, Harald E.4, Author           
Villringer, Arno2, 10, 11, Author           
Sacher, Julia1, 2, 10, Author           
Affiliations:
1Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
6Department of Psychology, Münster University, Germany, ou_persistent22              
7Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
8Division of Clinical Pharmacology, Rudolf-Boehm-Institute of Pharmacology and Toxicology, Leipzig, Germany, ou_persistent22              
9Centre for Cognition and Decision Making, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              
10Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
11MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Functional magnetic resonance imaging; Neural plasticity; Post-stroke motor dysfunction; Selective serotonin reuptake inhibitors; Sequential motor learning
 Abstract: The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we use functional magnetic resonance imaging in a double-blind, randomized controlled study to assess whether 20 mg escitalopram improves sequence-specific motor performance and modulates cortical motor response in 64 healthy female participants. We found decreased left premotor cortex responses during sequence-specific learning performance comparing single dose and steady escitalopram state. Escitalopram plasma levels negatively correlated with the premotor cortex response. We did not find evidence in support of improved motor performance after a week of escitalopram intake. These findings do not support the conclusion that one week escitalopram intake increases motor performance but could reflect early adaptive plasticity with improved neural processing underlying similar task performance when steady peripheral escitalopram levels are reached.

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Language(s): eng - English
 Dates: 2020-05-282020-09-042020-11-042021-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X20965161
Other: epub 2020
PMID: 33148103
 Degree: -

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Funding organization : FAZIT Foundation
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Funding program : Branco Weiss Fellowship
Funding organization : Society in Science
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Grant ID : -
Funding program : -
Funding organization : Max Planck Society

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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 41 (6) Sequence Number: - Start / End Page: 1449 - 1462 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202