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  Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference

Piai, V., Nieberlein, L., & Hartwigsen, G. (2020). Effects of transcranial magnetic stimulation over the left posterior superior temporal gyrus on picture-word interference. PLoS One, 15(11): e0242941. doi:10.1371/journal.pone.0242941.

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 Creators:
Piai, Vitoria1, 2, Author
Nieberlein, Laura3, Author
Hartwigsen, Gesa3, Author              
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
3Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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 Abstract: Word-production theories argue that during language production, a concept activates multiple lexical candidates in left temporal cortex, and the intended word is selected from this set. Evidence for theories on spoken-word production comes, for example, from the picture-word interference task, where participants name pictures superimposed by congruent (e.g., picture: rabbit, distractor "rabbit"), categorically related (e.g., distractor "sheep"), or unrelated (e.g., distractor "fork") words. Typically, whereas congruent distractors facilitate naming, related distractors slow down picture naming relative to unrelated distractors, resulting in semantic interference. However, the neural correlates of semantic interference are debated. Previous neuroimaging studies have shown that the left mid-to-posterior STG (pSTG) is involved in the interference associated with semantically related distractors. To probe the functional relevance of this area, we targeted the left pSTG with focal repetitive transcranial magnetic stimulation (rTMS) while subjects performed a picture-word interference task. Unexpectedly, pSTG stimulation did not affect the semantic interference effect but selectively increased the congruency effect (i.e., faster naming with congruent distractors). The facilitatory TMS effect selectively occurred in the more difficult list with an overall lower name agreement. Our study adds new evidence to the causal role of the left pSTG in the interaction between picture and distractor representations or processing streams, only partly supporting previous neuroimaging studies. Moreover, the observed unexpected condition-specific facilitatory rTMS effect argues for an interaction of the task- or stimulus-induced brain state with the modulatory TMS effect. These issues should be systematically addressed in future rTMS studies on language production.

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Language(s): eng - English
 Dates: 2020-08-092020-11-112020-11-30
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0242941
Other: eCollection 2020
PMID: 33253319
PMC: PMC7703954
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Grant ID : HA-6414/3-1; HA-6314/4-1
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Funding organization : German Research Foundation
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Grant ID : 451-17-003
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Funding organization : Netherlands Organisation for Scientific Research
Project name : -
Grant ID : 024.001.006
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research

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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 15 (11) Sequence Number: e0242941 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850