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  Coupling of hippocampal theta and ripples with pontogeniculooccipital waves

Ramirez-Villegas, J., Besserve, M., Murayama, Y., Evrard, H., Oeltermann, A., & Logothetis, N. (2021). Coupling of hippocampal theta and ripples with pontogeniculooccipital waves. Nature, 589(7840), 96-102. doi:10.1038/s41586-020-2914-4.

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https://www.nature.com/articles/s41586-020-2914-4.pdf (Verlagsversion)
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Ramirez-Villegas, JF1, Autor           
Besserve, M1, Autor           
Murayama, Y1, Autor           
Evrard, HC1, Autor           
Oeltermann, A1, Autor           
Logothetis, NK1, Autor           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep1. These changes require precise homeostatic control by subcortical neuromodulatory structures2. The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis.

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 Datum: 2020-112021-01
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1038/s41586-020-2914-4
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Titel: Nature
  Kurztitel : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 589 (7840) Artikelnummer: - Start- / Endseite: 96 - 102 Identifikator: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238