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  Coupling of hippocampal theta and ripples with pontogeniculooccipital waves

Ramirez-Villegas, J., Besserve, M., Murayama, Y., Evrard, H., Oeltermann, A., & Logothetis, N. (2021). Coupling of hippocampal theta and ripples with pontogeniculooccipital waves. Nature, 589(7840), 96-102. doi:10.1038/s41586-020-2914-4.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-6DFD-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-A517-5
Genre: Journal Article

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Ramirez-Villegas, JF1, 2, Author              
Besserve, M1, 2, Author              
Murayama, Y1, 2, Author              
Evrard, HC1, 2, Author              
Oeltermann, A1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The hippocampus has a major role in encoding and consolidating long-term memories, and undergoes plastic changes during sleep1. These changes require precise homeostatic control by subcortical neuromodulatory structures2. The underlying mechanisms of this phenomenon, however, remain unknown. Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently modulates hippocampal network events through phasic pontine waves known as pontogeniculooccipital waves (PGO waves). Two physiologically distinct types of PGO wave appear to occur sequentially, selectively influencing high-frequency ripples and low-frequency theta events, respectively. The two types of PGO wave are associated with opposite hippocampal spike-field coupling, prompting periods of high neural synchrony of neural populations during periods of ripple and theta instances. The coupling between PGO waves and ripples, classically associated with distinct sleep stages, supports the notion that a global coordination mechanism of hippocampal sleep dynamics by cholinergic pontine transients may promote systems and synaptic memory consolidation as well as synaptic homeostasis.

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 Dates: 2020-112021-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/s41586-020-2914-4
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 589 (7840) Sequence Number: - Start / End Page: 96 - 102 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238