English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Ligand Rearrangements at Fe/S Cofactors: Slow Isomerization of a Biomimetic [2Fe‐2S] Cluster

Bergner, M., Roy, L., Dechert, S., Neese, F., Ye, S., & Meyer, F. (2017). Ligand Rearrangements at Fe/S Cofactors: Slow Isomerization of a Biomimetic [2Fe‐2S] Cluster. Angewandte Chemie International Edition, 56(17), 4882-4886. doi:10.1002/anie.201612621.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Bergner, Marie1, Author
Roy, Lisa2, Author              
Dechert, Sebastian1, Author
Neese, Frank2, Author              
Ye, Shengfa2, Author              
Meyer, Franc1, Author
Affiliations:
1Universität Göttingen, Institut für Anorganische Chemie, Tammannstrasse 4, 37077 Göttingen, Germany, ou_persistent22              
2Research Department Neese, Max Planck Institute for Chemical Energy Conversion, Max Planck Society, ou_3023886              

Content

show
hide
Free keywords: bioinorganic chemistry; density functional calczlations; iron-sulfur clusters; kinetics; ligand rearrangement
 Abstract: Ligand exchange plays an important role in the biogenesis of Fe/S clusters, most prominently during cluster transfer from a scaffold protein to its target protein. Although in vivo and in vitro studies have provided some insight into this process, the microscopic details of the ligand exchange steps are mostly unknown. In this work, the kinetics of the ligand rearrangement in a biomimetic [2Fe‐2S] cluster with mixed S/N capping ligands have been studied. Two geometrical isomers of the cluster are present in solution, and mechanistic insight into the isomerization process was obtained by variable‐temperature 1H NMR spectroscopy. Combined experimental and computational results reveal that this is an associative process that involves the coordination of a solvent molecule to one of the ferric ions. The cluster isomerizes at least two orders of magnitude faster in its protonated and mixed‐valent states. These findings may contribute to a deeper understanding of cluster transfer and sensing processes occurring in Fe/S cluster biogenesis.

Details

show
hide
Language(s): eng - English
 Dates: 2016-12-292017-03-302017-04-18
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201612621
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 56 (17) Sequence Number: - Start / End Page: 4882 - 4886 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851