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  Solid phase synthesis in the development of magnetic resonance imaging probes

Connah, L., & Angelovski, G. (2020). Solid phase synthesis in the development of magnetic resonance imaging probes. Organic Chemistry Frontiers, 7(24), 4121-4141. doi:10.1039/D0QO00921K.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-7101-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-9815-6
Genre: Journal Article

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 Creators:
Connah, L1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: MRI has emerged as a very important tool in biomedical research and is an essential diagnostic method in clinical radiology today. Although it can be utilised as a standalone technique, the inherent low sensitivity of the method has led to the development of contrast agents (CAs) in order to improve the specificity of the measurement. Nevertheless, the preparation of such probes is often challenging using standard solution phase chemistry, resulting in limitations in CA diversity and ultimately their broader applications. Solid phase synthesis (SPS) has emerged as an alternative synthetic methodology that can assist in circumventing these issues to enable more complex and specific derivatives to be developed. This article aims to provide a concise overview of the strategies employed for MRI CAs developed using SPS synthetic methodologies and evaluate the outlook for the approach in future CA synthesis. Specifically, the development of ligands for T1-weighted imaging, chemical exchange saturation transfer and bioresponsive MRI CAs synthesised directly via SPS are discussed.

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 Dates: 2020-112020-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1039/D0QO00921K
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Title: Organic Chemistry Frontiers
  Abbreviation : Org. Chem. Front.
Source Genre: Journal
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Publ. Info: London : Royal Society of Chemistry
Pages: - Volume / Issue: 7 (24) Sequence Number: - Start / End Page: 4121 - 4141 Identifier: ISSN: 2052-4129
CoNE: https://pure.mpg.de/cone/journals/resource/2052-4129