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  Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia

Becker, S., Granert, O., Timmers, M., Pilotto, A., Van Nueten, L., Roeben, M., et al. (2021). Association of Hippocampal Subfields, CSF Biomarkers, and Cognition in Patients With Parkinson Disease Without Dementia. Neurology, 96(6), e904-e915. doi:10.1212/WNL.0000000000011224.

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Becker, S, Author
Granert, O, Author
Timmers, M, Author
Pilotto, A, Author
Van Nueten , L, Author
Roeben, M, Author
Salvadore, G, Author
Galpern, WR, Author
Streffer, J, Author
Scheffler, K1, 2, Author              
Maetzler, W, Author
Berg, D, Author
Liepelt Scarfone, I, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Objectives: To examine whether hippocampal volume loss is primarily associated with cognitive status or pathologic Amyloid-β 1-42 (Aβ42) levels, this study compared hippocampal subfield volumes between both Parkinson's Disease (PD) patients with (PD-MCI) and without (PD-CN) cognitive impairment and between patients with low and high Aβ42 levels, in addition exploring the relationship between hippocampal subfield volumes, CSF biomarkers (Aβ42, phosphorylated and total tau), neuropsychological tests, and activities of daily living. Methods: Forty-five non-demented PD patients underwent CSF analyses and magnetic resonance imaging as well as comprehensive motor and neuropsychological examinations. Hippocampal segmentation was conducted using FreeSurfer image analysis suite 6.0. Regression models were used to compare hippocampal subfield volumes between groups, and partial correlations defined the association between variables while controlling for intracranial volume (ICV). Results: Linear regressions revealed cognitive group as a statistically significant predictor of both the hippocampal-amygdaloid transition area (HATA; β = -0.23, 95% CI: -0.44 to -0.02) and the Cornu Ammonis 1 region (CA1; β = -0.28, 95% CI: -0.56 to -0.02), independent of disease duration and ICV, with PD-MCI patients showing significantly smaller volumes than PD-CN. In contrast, no subfields were predicted by Aβ42 levels. Smaller hippocampal volumes were associated with worse performance on memory, language, spatial working memory and executive functioning tests. The subiculum was negatively correlated with total tau levels (r = -0.37, 95% CI: -0.60 to -0.09). Conclusion: Cognitive status, but not CSF Aβ42, predicted hippocampal volumes, specifically the CA1 and HATA. Hippocampal subfields were associated with various cognitive domains, as well as with tau pathology.

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 Dates: 2020-112021-02
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1212/WNL.0000000000011224
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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 96 (6) Sequence Number: - Start / End Page: e904 - e915 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073