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  Autonomous directional motion of actin-containing cell-sized droplets

Haller, B., Jahnke, K., Weiss, M., Göpfrich, K., Platzman, I., & Spatz, J. P. (2021). Autonomous directional motion of actin-containing cell-sized droplets. Advanced Intelligent Systems, 3(5): 2000190, pp. 1-8. doi:10.1002/aisy.202000190.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-7175-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-2216-8
Genre: Journal Article

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 Creators:
Haller, Barbara1, Author           
Jahnke, Kevin, Author
Weiss, Marian1, Author           
Göpfrich, Kerstin, Author
Platzman, Ilia1, Author           
Spatz, Joachim Pius1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: actin; droplet-based microfluidics; Marangoni effect; motility; ; surfactants; synthetic biology
 Abstract: Cell motility is potentially the most apparent distinction of living matter, serving an essential purpose in single cells and multicellular organisms alike. Thus, the bottom‐up reconstitution of autonomous motion of cell‐sized compartments remains an exciting but challenging goal. Herein, actin‐driven Marangoni flows are engineered to generate rotational and translational motility of surfactant‐stabilized emulsion droplets. The interaction between actin filaments and the negatively charged block‐copolymer Krytox is identified as the driving force for Marangoni flows at the droplet interface. Tuning the actin–Krytox interplay, sustained autonomous unidirectional droplet rotation with 1.7 rot h−1 is achieved. Ultimately, this rotational motion is transformed into a translational rolling motion by introducing interactions between the droplets and the surface of the observation chamber. Accordingly, translational motility of actin‐containing droplets at velocities of 0.061 ± 0.014 μm s−1 is reported herein and an overall displacement of several hundreds of micrometers within 30 min is observed. These self‐propelled systems with biologically active molecules demonstrate how motility could be implemented for synthetic cells.

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Language(s): eng - English
 Dates: 2020-09-222020-08-122020-11-162021-05-01
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/aisy.202000190
 Degree: -

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Title: Advanced Intelligent Systems
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag
Pages: - Volume / Issue: 3 (5) Sequence Number: 2000190 Start / End Page: 1 - 8 Identifier: ISSN: 2640-4567
CoNE: https://pure.mpg.de/cone/journals/resource/2640-4567