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  Emergence of low-symmetry foldamers from single monomers

Pappas, C. G., Mandal, P. K., Liu, B., Kauffmann, B., Miao, X., Komáromy, D., et al. (2020). Emergence of low-symmetry foldamers from single monomers. Nature Chemistry, 12, 1180-1186. doi:10.1038/s41557-020-00565-2.

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Pappas, Charalampos G.1, Author
Mandal, Pradeep K.2, Author
Liu, Bin1, Author
Kauffmann, Brice3, Author
Miao, Xiaoming1, Author
Komáromy , Dávid1, Author
Hoffmann, Waldemar4, 5, Author              
Manz, Christian4, 5, Author              
Chang, Rayoon4, 5, Author              
Liu, Kai1, Author
Pagel, Kevin4, 5, Author              
Huc, Ivan2, Author
Otto, Sijbren1, Author
Affiliations:
1Centre for Systems Chemistry, Stratingh Institute, Groningen, the Netherlands, ou_persistent22              
2Department of Pharmacy and Center for Integrated Protein Science, Ludwig-Maximilians Universität, Munich, Germany, ou_persistent22              
3Université de Bordeaux, CNRS, INSERM, UMS3033, Institut Européen de Chimie et Biologie, Pessac, France, ou_persistent22              
4Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany, ou_persistent22              
5Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              

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 Abstract: Self-assembly is a powerful method to obtain large discrete functional molecular architectures. When using a single building block, self-assembly generally yields symmetrical objects in which all the subunits relate similarly to their neighbours. Here we report the discovery of a family of self-constructing cyclic macromolecules with stable folded conformations of low symmetry, which include some with a prime number (13, 17 and 23) of units, despite being formed from a single component. The formation of these objects amounts to the production of polymers with a perfectly uniform length. Design rules for the spontaneous emergence of such macromolecules include endowing monomers with a strong potential for non-covalent interactions that remain frustrated in competing entropically favoured yet conformationally restrained smaller cycles. The process can also be templated by a guest molecule that itself has an asymmetrical structure, which paves the way to molecular imprinting techniques at the level of single polymer chains.

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Language(s): eng - English
 Dates: 2019-12-052020-09-212020-11-202020-12
 Publication Status: Published in print
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41557-020-00565-2
 Degree: -

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Title: Nature Chemistry
  Abbreviation : Nat. Chem.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: 9 Volume / Issue: 12 Sequence Number: - Start / End Page: 1180 - 1186 Identifier: ISSN: 1755-4330
CoNE: https://pure.mpg.de/cone/journals/resource/1755-4330