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  Quantitative multi-parameter mapping optimized for the clinical routine

Cooper, G., Hirsch, S., Scheel, M., Brandt, A. U., Paul, F., Finke, C., et al. (2020). Quantitative multi-parameter mapping optimized for the clinical routine. Frontiers in Neuroscience, 14: 611194. doi:10.3389/fnins.2020.611194.

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 Creators:
Cooper, Graham1, 2, 3, 4, Author
Hirsch, Sebastian5, 6, Author
Scheel, Michael1, 7, Author
Brandt, Alexander U.1, 8, Author
Paul, Friedemann1, 2, 3, 9, Author
Finke, Carsten3, 9, 10, Author
Boehm-Sturm, Philipp4, 11, Author
Hetzer, Stefan5, 6, Author
Ashburner, John12, Editor
Yarnykh, Vasily13, Referee
Leutritz, Tobias14, Referee              
Affiliations:
1NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
2Experimental and Clinical Research Centre, Charité University Medicine Berlin, Germany, ou_persistent22              
3Einstein Center for Neurosciences Berlin (ECN), Berlin, Germany, ou_persistent22              
4Department of Experimental Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
5Berlin Center for Advanced Neuroimaging (BCAN), Charité University Medicine Berlin, Germany, ou_persistent22              
6Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              
7Department of Neuroradiology, Charité University Medicine Berlin, Germany, ou_persistent22              
8Department of Neurology, University of California, Irvine, CA, USA, ou_persistent22              
9Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
10Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
11Core Facility 7T Experimental MRIs, NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
12UCL Queen Square Institute of Neurology, University College London, United Kingdom, ou_persistent22              
13University of Washington, Seattle, WA, USA, ou_persistent22              
14Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Quantitative multi-parameter mapping; Intra-subject reliability; Gibb's ringing; Quantitative MRI; Signal-to-noise-ratio
 Abstract: Using quantitative multi-parameter mapping (MPM), studies can investigate clinically relevant microstructural changes with high reliability over time and across subjects and sites. However, long acquisition times (20 min for the standard 1-mm isotropic protocol) limit its translational potential. This study aimed to evaluate the sensitivity gain of a fast 1.6-mm isotropic MPM protocol including post-processing optimized for longitudinal clinical studies. 6 healthy volunteers (35±7 years old; 3 female) were scanned at 3T to acquire the following whole-brain MPM maps with 1.6 mm isotropic resolution: proton density (PD), magnetization transfer saturation (MT), longitudinal relaxation rate (R1), and transverse relaxation rate (R2*). MPM maps were generated using two RF transmit field (B1+) correction methods: (1) using an acquired B1+ map and (2) using a data-driven approach. Maps were generated with and without Gibb's ringing correction. The intra-/inter-subject coefficient of variation (CoV) of all maps in the gray and white matter, as well as in all anatomical regions of a fine-grained brain atlas, were compared between the different post-processing methods using Student's t-test. The intra-subject stability of the 1.6-mm MPM protocol is 2–3 times higher than for the standard 1-mm sequence and can be achieved in less than half the scan duration. Intra-subject variability for all four maps in white matter ranged from 1.2–5.3% and in gray matter from 1.8 to 9.2%. Bias-field correction using an acquired B1+ map significantly improved intra-subject variability of PD and R1 in the gray (42%) and white matter (54%) and correcting the raw images for the effect of Gibb's ringing further improved intra-subject variability in all maps in the gray (11%) and white matter (10%). Combining Gibb's ringing correction and bias field correction using acquired B1+ maps provides excellent stability of the 7-min MPM sequence with 1.6 mm resolution suitable for the clinical routine.

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Language(s): eng - English
 Dates: 2020-09-282020-11-162020-12-07
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2020.611194
 Degree: -

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Project name : -
Grant ID : #276880906; #39052203
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Funding organization : Deutsche Forschungsgemeinschaft

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 14 Sequence Number: 611194 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548