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  Penetration of amphiphilic quantum dots through model and cellular plasma membranes

Dubavik, A., Sezgin, E., Lesnyak, V., Gaponik, N., Schwille, P., & Eychmüller, A. (2012). Penetration of amphiphilic quantum dots through model and cellular plasma membranes. ACS Nano, 6(3), 2150-2156. doi:10.1021/nn204930y.

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 Creators:
Dubavik, Aliaksei, Author
Sezgin, Erdinc, Author
Lesnyak, Vladimir, Author
Gaponik, Nikolai, Author
Schwille, Petra1, Author           
Eychmüller, Alexander, Author
Affiliations:
1Biophysics/BIOTEC, TU Dresden, ou_persistent22              

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Free keywords: amphiphilic CdTe nanocrystals colloidal synthesis photoluminescence giant unilamellar vesicles giant plasma membrane vesicles penetration through the cell membrane endocytosis
 Abstract: In this work we demonstrate progress in the colloidal synthesis of amphiphilic CdTe nanocrystals stabilized by thiolated PEG oligomers with the aim of facilitating cellular uptake of the particles. High-boiling, good coordinating solvents such as dimethylacetamide and dimethylformamide accelerate the growth of the nanoparticles yielding stable colloids of which photoluminescence maxima can be tuned to cover the region of 540-640 nm with quantum yields of up to 30%. The CdTe nanocrystals capped by thiolated methoxypolyethylene glycol are shown to penetrate through the lipid bilayer of giant unilamellar vesicles and giant plasma membrane vesicles which constitute basic endocytosis-free model membrane systems. Moreover, the penetration of amphiphilic particles through live cell plasma membranes and their ability to escape the endocytic pathway have been demonstrated.

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 Dates: 2012
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/nn204930y
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Title: ACS Nano
  Other : ACS Nano
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 6 (3) Sequence Number: - Start / End Page: 2150 - 2156 Identifier: ISSN: 1936-0851
CoNE: https://pure.mpg.de/cone/journals/resource/1936-0851