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  Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions

Wang, G., & Angelovski, G. (2020). Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions. Angewandte Chemie International Edition, Epub ahead. doi:10.1002/anie.202014431.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-7563-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-7564-5
Genre: Journal Article

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Wang, G1, 2, Author              
Angelovski, G1, 2, Author              
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Zinc ions play an important role in numerous crucial biological processes in the human body. The ability to image the function of Zn 2+ would be a significant asset to biomedical research for monitoring various physiopathologies dependent on its fate. To this end, we developed a novel Gd 3+ chelate that can selectively recognize Zn 2+ over other abundant endogenous metal ions and alter its paramagnetic properties. More specifically, this lanthanide chelate displayed an extraordinary increase in longitudinal relaxivity ( r 1 ) of over 400% upon interaction with Zn 2+ at 7 T and 25 °C, which is the greatest r 1 enhancement observed for any of the metal ion-responsive Gd-based complexes at high magnetic field. A "turn-on" mechanism responsible for these massive changes was confirmed through NMR and luminescence lifetime studies on a 13 C-labeled Eu 3+ analogue. This molecular platform represents a new momentum in developing highly suitable magnetic resonance imaging contrast agents for functional molecular imaging studies of Zn 2+ .

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 Dates: 2020-11
 Publication Status: Published online
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 Identifiers: DOI: 10.1002/anie.202014431
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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851