English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations

Cudalbu, C., Behar, K., Bhattacharyya, P., Bogner, W., Borbath, T., de Graaf, R., et al. (2020). Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations. NMR in Biomedicine, Epub ahead. doi:10.1002/nbm.4393.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0007-76FD-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-76FF-6
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Cudalbu, C, Author
Behar, KL, Author
Bhattacharyya, PK, Author
Bogner, W, Author
Borbath, T1, 2, Author              
de Graaf, RA, Author
Gruetter, R, Author
Henning, A1, 2, Author              
Juchem, C, Author
Kreis, R, Author
Lee, P, Author
Lei, H, Author
Marjanska, M, Author
Mekle, R, Author
Murali-Manohar, S1, 2, Author              
Považan, M, Author
Rackayová, V, Author
Simicic, D, Author
Slotboom, J, Author
Soher, BJ, Author
Starčuk, Z, AuthorStarčukova, J, AuthorTkáč, I, AuthorWilliams, S, AuthorWilson, M, AuthorWright, AM, AuthorXin, L, AuthorMlynárik, V, Author more..
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.

Details

show
hide
Language(s):
 Dates: 2020-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/nbm.4393
eDoc: e4393
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: NMR in Biomedicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Heyden & Son
Pages: - Volume / Issue: Epub ahead Sequence Number: - Start / End Page: - Identifier: ISSN: 0952-3480
CoNE: https://pure.mpg.de/cone/journals/resource/954925574973