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  Reduced olfactory bulb volume in obesity and its relation to metabolic health status

Poessel, M., Breuer, N., Joshi, A., Pampel, A., Villringer, A., Hummel, T., et al. (2020). Reduced olfactory bulb volume in obesity and its relation to metabolic health status. Frontiers in Human Neuroscience, 14: 586998. doi:10.3389/fnhum.2020.586998.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-7A31-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-7A32-8
Genre: Journal Article

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 Creators:
Poessel, Maria1, 2, Author              
Breuer, Nora1, 2, Author              
Joshi, Akshita3, Author
Pampel, André4, Author              
Villringer, Arno1, 5, 6, 7, 8, 9, Author              
Hummel, Thomas3, Author
Horstmann, Annette1, 2, 10, 11, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Smell and Taste Clinic, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              
4Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
5Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Charité University Medicine Berlin, Germany, ou_persistent22              
8International Max Planck Research School on the Life Course, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
9International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
10Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
11Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Olfactory bulb; Obesity; Olfaction; Smell perception; HOMA-IR; Metabolic health
 Abstract: Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin’ Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs.

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Language(s): eng - English
 Dates: 2020-07-242020-11-032020-11-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnhum.2020.586998
 Degree: -

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Project name : -
Grant ID : 01EO1501
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Funding organization : Federal Ministry of Education and Research (BMBF)

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Title: Frontiers in Human Neuroscience
  Abbreviation : Front Hum Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 14 Sequence Number: 586998 Start / End Page: - Identifier: ISSN: 1662-5161
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5161