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  Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels

Zhang, M., Sun, Q., Liu, Y., Chu, Z., Yu, L., Hou, Y., et al. (2020). Controllable ligand spacing stimulates cellular mechanotransduction and promotes stem cell osteogenic differentiation on soft hydrogels. Biomaterials, 268: 120543, pp. 1-12. doi:10.1016/j.biomaterials.2020.120543.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-7A91-C Version Permalink: https://hdl.handle.net/21.11116/0000-0007-7A92-B
Genre: Journal Article

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 Creators:
Zhang, Man1, Author           
Sun, Qian, Author
Liu, Yiling, Author
Chu, Zhiqin, Author
Yu, Leixiao, Author
Hou, Yong, Author
Kang, Heemin, Author
Wei, Qiang, Author
Zhao, Weifeng, Author
Spatz, Joachim P.1, Author           
Zhao, Changsheng, Author
Cavalcanti-Adam, Elisabetta Ada1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: Ligand spacing; Mechanotransduction; Mesenchymal stem cell; Differentiation; Hydrogel
 Abstract: Hydrogels with tunable mechanical properties have provided a tremendous opportunity to regulate stem cell differentiation. Hydrogels with osteoid (about 30–40 kPa) or higher stiffness are usually required to induce the osteogenic differentiation of mesenchymal stem cells (MSCs). It is yet difficult to achieve the same differentiation on very soft hydrogels, because of low environmental mechanical stimuli and restricted cellular mechanotransduction. Here, we modulate cellular spatial sensing of integrin-adhesive ligands via quasi-hexagonally arranged nanopatterns to promote cell mechanosensing on hydrogels having low stiffness (about 3 kPa). The increased interligand spacing has been shown to regulate actomyosin force loading to recruit extra integrins on soft hydrogels. It therefore activates mechanotransduction and promotes the osteogenic differentiation of MSCs on soft hydrogels to the level comparable with the one observed on osteoid stiffness. Our work opens up new possibilities for the design of biomaterials and tissue scaffolds for regenerative therapeutics.

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Language(s): eng - English
 Dates: 2020-11-132020-06-052020-11-162020-11-23
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.biomaterials.2020.120543
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Title: Biomaterials
Source Genre: Journal
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Publ. Info: Guildford, England : Elsevier
Pages: - Volume / Issue: 268 Sequence Number: 120543 Start / End Page: 1 - 12 Identifier: ISSN: 0142-9612
CoNE: https://pure.mpg.de/cone/journals/resource/954925472369