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  Preservation of language processing and auditory performance in patients with disorders of consciousness: a multimodal assessment

Ferraro, S., Nigri, A., D'incerti, L., Rosazza, C., Sattin, D., Sebastiano, D. R., et al. (2020). Preservation of language processing and auditory performance in patients with disorders of consciousness: a multimodal assessment. Frontiers in Neurology, 11: 526465. doi:10.3389/fneur.2020.526465.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-7AE0-3 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-9C08-1
Genre: Journal Article

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2020
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Copyright © 2020 Ferraro, Nigri, D'Incerti, Rosazza, Sattin, Rossi Sebastiano, Visani, Duran, Marotta, Demichelis, Catricala', Kotz, Verga, Leonardi, Cappa and Bruzzone. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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http://creativecommons.org/licenses/by/4.0/

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Ferraro, S., Author
Nigri, A., Author
D'incerti, L., Author
Rosazza, C., Author
Sattin, D., Author
Sebastiano, Davide R., Author
Visani, E., Author
Duran, D., Author
Marotta, G., Author
De Michelis, G., Author
Catricalà, E., Author
Kotz, Sonja A., Author
Verga, Laura1, Author           
Leonardi, M., Author
Cappa, S. F., Author
Bruzzone, M. G., Author
Affiliations:
1Maastricht University, Maastricht, The Netherlands, ou_persistent22              

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 Abstract: The impact of language impairment on the clinical assessment of patients suffering from disorders of consciousness (DOC) is unknown or underestimated, and may mask the presence of conscious behavior. In a group of DOC patients (n=11; time post-injury range:5-252 months), we investigated the main neural functional and structural underpinnings of linguistic processing, and their relationship with the behavioral measures of the auditory function, using the Coma Recovery Scale-Revised (CRS-R). We assessed the integrity of the brainstem auditory pathways, of the left superior temporal gyrus and arcuate fasciculus, the neural activity elicited by passive listening of an auditory language task and the mean hemispheric glucose metabolism.
Our results support the hypothesis of a relationship between the level of preservation of the investigated structures/functions and the CRS-R auditory subscale scores.
Moreover, our findings indicate that patients in minimally conscious state minus (MCS-): 1) when presenting the \emph{auditory startle} (at the CRS-R auditory subscale) might be aphasic in the receptive domain, being severely impaired in the core language structures/functions; 2) when presenting the \emph{localization to sound} might retain language processing, being almost intact or intact in the core language structures/functions. Despite the small group of investigated patients, our findings provide a grounding of the clinical measures of the CRS-R auditory subscale in the integrity of the underlying auditory structures/functions. Future studies are needed to confirm our results that might have important consequences for the clinical practice.

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Language(s): eng - English
 Dates: 2020-10-222020-12-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fneur.2020.526465
 Degree: -

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Title: Frontiers in Neurology
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 526465 Start / End Page: - Identifier: ISSN: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295