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  The mouse alpha-globin cluster: A paradigm for studying genome regulation and organization

Oudelaar, A. M., Beagrie, R. A., Kassouf, M. T., & Higgs, D. R. (2021). The mouse alpha-globin cluster: A paradigm for studying genome regulation and organization. Current Opinion in Genetics and Development, 67, 18-24. doi:10.1016/j.gde.2020.10.003.

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Oudelaar, A. M.1, Author           
Beagrie, R. A., Author
Kassouf, M. T., Author
Higgs, D. R., Author
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1Lise Meitner Group Genome Organization and Regulation, MPI for Biophysical Chemistry, Max Planck Society, ou_3261271              

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 Abstract: The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expression of the α-globin cluster change. The gradual activation of the α-globin genes in well-defined cell populations has enabled investigation of the structural and functional roles of its enhancers, promoters and boundary elements. Recent studies of gene regulatory processes involving these elements at the mouse α-globin cluster have brought new insights into the general principles underlying the three-dimensional structure of the genome and its relationship to gene expression throughout time.

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Language(s): eng - English
 Dates: 2020-11-192021-04
 Publication Status: Published in print
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 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.gde.2020.10.003
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Title: Current Opinion in Genetics and Development
Source Genre: Journal
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Pages: - Volume / Issue: 67 Sequence Number: - Start / End Page: 18 - 24 Identifier: -