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  The multimodal Ganzfeld-induced altered state of consciousness induces decreased thalamo-cortical coupling

Schmidt, T. T., Jagannathan, N., Ljubljanac, M., Xavier, A., & Nierhaus, T. (2020). The multimodal Ganzfeld-induced altered state of consciousness induces decreased thalamo-cortical coupling. Scientific Reports, 10: 18686. doi:10.1038/s41598-020-75019-3.

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Schmidt, Timo Torsten1, 2, Author
Jagannathan, Nisha2, Author
Ljubljanac, Michal2, Author
Xavier, Ann2, Author
Nierhaus, Till1, 3, Author              
Affiliations:
1Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, FU Berlin, Germany , ou_persistent22              
2Institute of Cognitive Science, University of Osnabrück, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Different pharmacologic agents have been used to investigate the neuronal underpinnings of alterations in consciousness states, such as psychedelic substances. Special attention has been drawn to the role of thalamic filtering of cortical input. Here, we investigate the neuronal mechanisms underlying an altered state of consciousness (ASC) induced by a non-pharmacological procedure. During fMRI scanning, N = 19 human participants were exposed to multimodal Ganzfeld stimulation, a technique of perceptual deprivation where participants are exposed to intense, unstructured, homogenous visual and auditory stimulation. Compared to pre- and post-resting-state scans, the Ganzfeld data displayed a progressive decoupling of the thalamus from the cortex. Furthermore, the Ganzfeld-induced ASC was characterized by increased eigenvector centrality in core regions of the default mode network (DMN). Together, these findings can be interpreted as an imbalance of sensory bottom-up signaling and internally-generated top-down signaling. This imbalance is antithetical to psychedelic-induced ASCs, where increased thalamo-cortical coupling and reduced DMN activity were observed.

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Language(s): eng - English
 Dates: 2020-02-112020-10-092020-10-29
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-020-75019-3
PMID: 33122651
PMC: PMC7596232
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 Sequence Number: 18686 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322