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  Methodological considerations for neuroimaging in deep brain stimulation of the subthalamic nucleus in Parkinson’s disease patients

Isaacs, B. R., Keuken, M. C., Alkemade, A., Temel, Y., Bazin, P.-L., & Forstmann, B. U. (2020). Methodological considerations for neuroimaging in deep brain stimulation of the subthalamic nucleus in Parkinson’s disease patients. Journal of Clinical Medicine, 9(10): 3124. doi:10.3390/jcm9103124.

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 Creators:
Isaacs, Bethany R.1, 2, Author
Keuken, Max C.3, Author
Alkemade, Anneke1, Author
Temel, Yasin2, Author
Bazin, Pierre-Louis1, 4, Author              
Forstmann, Birte U.1, Author
Affiliations:
1Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands, ou_persistent22              
2Department of Neurosurgery, Maastricht University, the Netherlands, ou_persistent22              
3Services & Data, Cluster Social, Municipality of Amsterdam, the Netherlands, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Parkinson’s disease; Magnetic resonance imaging; Deep brain stimulation; Ultra-high field
 Abstract: Deep brain stimulation (DBS) of the subthalamic nucleus is a neurosurgical intervention for Parkinson’s disease patients who no longer appropriately respond to drug treatments. A small fraction of patients will fail to respond to DBS, develop psychiatric and cognitive side-effects, or incur surgery-related complications such as infections and hemorrhagic events. In these cases, DBS may require recalibration, reimplantation, or removal. These negative responses to treatment can partly be attributed to suboptimal pre-operative planning procedures via direct targeting through low-field and low-resolution magnetic resonance imaging (MRI). One solution for increasing the success and efficacy of DBS is to optimize preoperative planning procedures via sophisticated neuroimaging techniques such as high-resolution MRI and higher field strengths to improve visualization of DBS targets and vasculature. We discuss targeting approaches, MRI acquisition, parameters, and post-acquisition analyses. Additionally, we highlight a number of approaches including the use of ultra-high field (UHF) MRI to overcome limitations of standard settings. There is a trade-off between spatial resolution, motion artifacts, and acquisition time, which could potentially be dissolved through the use of UHF-MRI. Image registration, correction, and post-processing techniques may require combined expertise of traditional radiologists, clinicians, and fundamental researchers. The optimization of pre-operative planning with MRI can therefore be best achieved through direct collaboration between researchers and clinicians.

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Language(s): eng - English
 Dates: 2020-09-172020-08-242020-09-252020-09-27
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/jcm9103124
PMID: 32992558
PMC: PMC7600568
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Title: Journal of Clinical Medicine
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 9 (10) Sequence Number: 3124 Start / End Page: - Identifier: ISSN: 2077-0383
CoNE: https://pure.mpg.de/cone/journals/resource/2077-0383