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  Retracing the evolutionary emergence of thymopoiesis

Swann, J., Nusser, A., Morimoto, R., Nagakubo, D., & Boehm, T. (2020). Retracing the evolutionary emergence of thymopoiesis. Science Advances, 6: eabd9585. doi:10.1126/sciadv.abd9585.

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2020
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 Creators:
Swann, Jeremy1, Author           
Nusser, Anja1, Author           
Morimoto, Ryo1, Author           
Nagakubo, Daisuke1, Author
Boehm, Thomas1, Author           
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1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647              

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 Abstract: The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the Foxn1/4 transcription factor gene family, which direct the differentiation of the thymic microenvironment. Molecular engineering in transgenic mice recapitulated a gene duplication event, exon replacements, and altered expression patterns. These changes predictably modified the lymphopoietic characteristics of the thymus, identifying molecular features contributing to conversion of a primordial bipotent lymphoid organ to a tissue specializing in T cell development. The phylogenetic reconstruction associates increasing efficiency of T cell generation with diminishing B cell–generating capacity of the thymus during jawed vertebrate evolution.

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Language(s): eng - English
 Dates: 2020-11-27
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/sciadv.abd9585
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Title: Science Advances
  Other : Sci. Adv.
Source Genre: Journal
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Publ. Info: Washington : AAAS
Pages: - Volume / Issue: 6 Sequence Number: eabd9585 Start / End Page: - Identifier: ISSN: 2375-2548
CoNE: https://pure.mpg.de/cone/journals/resource/2375-2548