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  Expamers: a new technology to control T cell activation

Poltorak, M. P., Graef, P., Tschulik, C., Wagner, M., Cletiu, V., Dreher, S., et al. (2020). Expamers: a new technology to control T cell activation. Scientific Reports, 10(1): 17832. doi:10.1038/s41598-020-74595-8.

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 Creators:
Poltorak, Mateusz P.1, Author
Graef, Patricia1, Author
Tschulik, Claudia1, Author
Wagner, Michaela1, Author
Cletiu, Vlad1, Author
Dreher, Stefan1, Author
Borjan, Bojana1, Author
Fraessle, Simon P.1, Author
Effenberger, Manuel1, Author
Turk, Martin2, Author              
Busch, Dirk H.1, Author
Plitzko, Jürgen2, Author              
Kugler, David G.1, Author
Ragan, Seamus1, Author
Schmidt, Thomas1, Author
Stemberger, Christian1, Author
Germeroth, Lothar1, Author
Affiliations:
1external, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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Free keywords: AFFINITY PEPTIDE; ANTIGEN; PROLIFERATION; MEMORY; COSTIMULATION; PURIFICATION; STIMULATION; POPULATIONS; EXPRESSION; INDUCTIONScience & Technology - Other Topics;
 Abstract: T cell activation is a cornerstone in manufacturing of T cell-based therapies, and precise control over T cell activation is important in the development of the next generation T-cell based therapeutics. This need cannot be fulfilled by currently available methods for T cell stimulation, in particular not in a time dependent manner. Here, we describe a modular activation reagent called Expamers, which addresses these limitations. Expamers are versatile stimuli that are intended for research and clinical use. They are readily soluble and can be rapidly bound and removed from the cell surface, allowing nearly instantaneous initiation and termination of activation signal, respectively. Hence, Expamers enable precise regulation of T cell stimulation duration and provide promise of control over T cell profiles in future products. Expamers can be easily adopted to different T cell production formats and have the potential to increase efficacy of T cell immunotherapeutics.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 15
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 Table of Contents: -
 Rev. Type: -
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 17832 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322