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  Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control

Sitron, C. S., & Brandman, O. (2020). Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control. Annual Review of Biochemistry, 89(1), 417-442. doi:10.1146/annurev-biochem-013118-110729.

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 Creators:
Sitron, Cole S.1, Author           
Brandman, Onn2, Author
Affiliations:
1Hartl, Franz-Ulrich / Cellular Biochemistry, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565152              
2external, ou_persistent22              

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Free keywords: MESSENGER-RNA SURVEILLANCE; E3 UBIQUITIN LIGASE; RELEASE FACTOR ERF3; TRANSLATION TERMINATION; STRUCTURAL BASIS; IN-VIVO; ENDONUCLEOLYTIC CLEAVAGE; TRANSCRIPTION FACTOR; PROTEIN AGGREGATION; BETA-SUBUNITBiochemistry & Molecular Biology; ribosome stalling; translation; RQC; CAT tails; protein degradation; ubiquitin;
 Abstract: Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
 Pages: 26
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Annual Review of Biochemistry
Source Genre: Journal
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Publ. Info: Palo Alto, Calif. : Stanford University Press
Pages: - Volume / Issue: 89 (1) Sequence Number: - Start / End Page: 417 - 442 Identifier: ISSN: 0066-4154
CoNE: https://pure.mpg.de/cone/journals/resource/954925458038