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Free keywords:
MESSENGER-RNA SURVEILLANCE; E3 UBIQUITIN LIGASE; RELEASE FACTOR ERF3;
TRANSLATION TERMINATION; STRUCTURAL BASIS; IN-VIVO; ENDONUCLEOLYTIC
CLEAVAGE; TRANSCRIPTION FACTOR; PROTEIN AGGREGATION; BETA-SUBUNITBiochemistry & Molecular Biology; ribosome stalling; translation; RQC; CAT tails; protein degradation;
ubiquitin;
Abstract:
Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.
