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  The genetic architecture of structural left–right asymmetry of the human brain

Sha, Z., Schijven, D., Carrion Castillo, A., Joliot, M., Mazoyer, B., Fisher, S. E., et al. (2021). The genetic architecture of structural left–right asymmetry of the human brain. Nature Human Behaviour, 5, 1226-1236. doi:10.1038/s41562-021-01069-w.

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Sha_etal_2021_Genetic architecture of structural left-right asymmetry of the human brain.pdf (Publisher version), 3MB
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Sha_etal_2021_Genetic architecture of structural left-right asymmetry of the human brain.pdf
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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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 Creators:
Sha, Zhiqiang1, Author           
Schijven, Dick1, Author           
Carrion Castillo, Amaia1, Author           
Joliot, Marc2, Author
Mazoyer, Bernard2, Author
Fisher, Simon E.1, 3, Author           
Crivello, Fabrice2, Author
Francks, Clyde1, 3, 4, Author           
Affiliations:
1Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
2Université de Bordeaux, Bordeaux, France, ou_persistent22              
3Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
4Imaging Genomics, MPI for Psycholinguistics, Max Planck Society, ou_2579692              

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 Abstract: Left–right hemispheric asymmetry is an important aspect of healthy brain organization for many functions including language, and it can be altered in cognitive and psychiatric disorders. No mechanism has yet been identified for establishing the human brain’s left–right axis. We performed multivariate genome-wide association scanning of cortical regional surface area and thickness asymmetries, and subcortical volume asymmetries, using data from 32,256 participants from the UK Biobank. There were 21 significant loci associated with different aspects of brain asymmetry, with functional enrichment involving microtubule-related genes and embryonic brain expression. These findings are consistent with a known role of the cytoskeleton in left–right axis determination in other organs of invertebrates and frogs. Genetic variants associated with brain asymmetry overlapped with those associated with autism, educational attainment and schizophrenia. Comparably large datasets will likely be required in future studies, to replicate and further clarify the associations of microtubule-related genes with variation in brain asymmetry, behavioural and psychiatric traits.

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Language(s): eng - English
 Dates: 2020-122021-03-152021-09
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41562-021-01069-w
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Title: Nature Human Behaviour
Source Genre: Journal
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Publ. Info: London : Nature Research
Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 1226 - 1236 Identifier: ISSN: 2397-3374
CoNE: https://pure.mpg.de/cone/journals/resource/2397-3374