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  Systematic structural characterization of chitooligosaccharides enabled by Automated Glycan Assembly

Tyrikos-Ergas, T., Bordoni, V., Fittolani, G., Chaube, M., Grafmüller, A., Seeberger, P. H., et al. (2021). Systematic structural characterization of chitooligosaccharides enabled by Automated Glycan Assembly. Chemistry – A European Journal, 27(7), 2321-2325. doi:10.1002/chem.202005228.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-92AD-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-DDBA-F
Genre: Journal Article

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Tyrikos-Ergas, Theodore1, Author              
Bordoni, Vittorio1, Author              
Fittolani, Giulio1, Author              
Chaube, Manishkumar1, Author              
Grafmüller, Andrea2, Author              
Seeberger, Peter H.3, Author              
Delbianco, Martina1, Author              
Affiliations:
1Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              
2Andrea Grafmüller, Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863323              
3Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: carbohydrates, Chitin, Chitosan, MD simulations, structure-property correlations
 Abstract: Chitin, a polymer composed of β(1-4)-linked N-acetyl-glucosamine monomers, and its partially deacetylated analogue chitosan, are abundant biopolymers with outstanding mechanical as well as elastic properties. Their degradation products, chitooligosaccharides (COS), can trigger the innate immune response in humans and plants. Both material and biological properties are dependent on polymer length, acetylation, as well as the pH. Without well-defined samples, a complete molecular description of these factors is still missing. Automated Glycan Assembly (AGA) enabled rapid access to synthetic well-defined COS. Chitin-cellulose hybrid oligomers were prepared as important tools for a systematic structural analysis. Intramolecular interactions, identified by molecular dynamics simulations and NMR analysis, underscore the importance of the chitosan amino group for the stabilization of specific geometries.

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Language(s): eng - English
 Dates: 2020-12-082021
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1002/chem.202005228
BibTex Citekey: https://doi.org/10.1002/chem.202005228
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Title: Chemistry – A European Journal
  Other : Chem. – Eur. J.
  Other : Chem. Eur. J.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 27 (7) Sequence Number: - Start / End Page: 2321 - 2325 Identifier: ISSN: 0947-6539