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  A seven-WD40 protein related to human RACK1 regulates mating and virulence in Ustilago maydis

Wang, L., Berndt, P., Xia, X. J., Kahnt, J., & Kahmann, R. (2011). A seven-WD40 protein related to human RACK1 regulates mating and virulence in Ustilago maydis. Molecular Microbiology, 81(6), 1484-1498. doi:10.1111/j.1365-2958.2011.07783.x.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0007-C1DD-6 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-6D0C-D
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 Urheber:
Wang, L.1, Autor           
Berndt, P.1, Autor           
Xia, X. J.2, Autor
Kahnt, J.3, Autor           
Kahmann, R.4, Autor           
Affiliations:
1Department of Organismic Interactions, Alumni, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266313              
2Max Planck Society, ou_persistent13              
3Department of Ecophysiology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266280              
4Emeriti Molecular Phytopathology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266291              

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 Zusammenfassung: In mammalian cells RACK1 serves as a scaffold protein that has a role in integrating inputs from different signalling pathways and affects translation through association with ribosomes. Ustilago maydis contains a seven-WD40 repeat motif protein designated Rak1, which shows 68% identity to RACK1 and 51% identity to Asc1p of Saccharomyces cerevisiae. An asc1 mutant could be complemented by introduction of U. maydis rak1. The deletion of rak1 affected cell growth, cell wall integrity and specifically attenuated cell fusion. This latter defect was caused by reduced expression of prf1 encoding the regulator for pheromone (mfa) and pheromone-receptor genes. Rak1 interacts with a variety of ribosomal proteins and microarray analysis revealed that the deletion of rak1 led to severely reduced expression of rop1, a transcriptional activator of prf1. The constitutive expression of rop1 could rescue the defect of mfa1 expression as well as conjugation tube formation in response to pheromone induction in the rak1 mutant. Moreover, a solopathogenic rak1 mutant failed to respond to plant-derived stimuli, resulting in attenuated filamentation and pathogenicity. This could be partially rescued by constitutive expression of the b heterodimer. These data suggest that rak1 is a regulator of rop1 expression with additional roles after cell fusion.

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Sprache(n): eng - English
 Datum: 2011-09
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 583230
ISI: 000295087000007
DOI: 10.1111/j.1365-2958.2011.07783.x
 Art des Abschluß: -

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Titel: Molecular Microbiology
  Alternativer Titel : Mol. Microbiol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: MALDEN : WILEY-BLACKWELL
Seiten: - Band / Heft: 81 (6) Artikelnummer: - Start- / Endseite: 1484 - 1498 Identifikator: ISSN: 0950-382X