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  Synchronization of Chromosome Dynamics and Cell Division in Bacteria

Thanbichler, M. (2009). Synchronization of Chromosome Dynamics and Cell Division in Bacteria. Cold Spring Harbor Perspectives in Biology, 2(1), a000331. doi:10.1101/cshperspect.a000331.

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 Creators:
Thanbichler, Martin1, Author           
Affiliations:
1Max Planck Fellow Bacterial Cell Biology, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266301              

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 Abstract: Bacterial cells have evolved a variety of regulatory circuits that tightly synchronize their chromosome replication and cell division cycles, thereby ensuring faithful transmission of genetic information to their offspring. Complex multicomponent signaling cascades are used to monitor the progress of cytokinesis and couple replication initiation to the separation of the two daughter cells. Moreover, the cell-division apparatus actively participates in chromosome partitioning and, particularly, in the resolution of topological problems that impede the segregation process, thus coordinating chromosome dynamics with cell constriction. Finally, bacteria have developed mechanisms that harness the cell-cycle-dependent positioning of individual chromosomal loci or the nucleoid to define the cell-division site and control the timing of divisome assembly. Each of these systems manages to integrate a complex set of spatial and temporal cues to regulate and execute critical steps in the bacterial cell cycle.

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Language(s): eng - English
 Dates: 2009-11-18
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 498475
DOI: 10.1101/cshperspect.a000331
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Title: Cold Spring Harbor Perspectives in Biology
  Alternative Title : Cold Spring Harb Perspect Biol
Source Genre: Journal
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Pages: - Volume / Issue: 2 (1) Sequence Number: - Start / End Page: a000331 Identifier: -