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  3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings

Isaacs, B. R., Mulder, M. J., Groot, J. M., van Berendonk, N., Lute, N., Bazin, P.-L., et al. (2020). 3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings. PLoS One, 15(11): e0236208. doi:10.1371/journal.pone.0236208.

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 Creators:
Isaacs, Bethany R.1, 2, Author
Mulder, Martijn J.1, 3, Author
Groot, Josephine M.1, Author
van Berendonk, Nikita1, Author
Lute, Nicky1, 4, Author
Bazin, Pierre-Louis1, 5, Author              
Forstmann, Birte U.1, Author
Alkemade, Anneke1, Author
Affiliations:
1Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands, ou_persistent22              
2Department of Neurosurgery, Maastricht University, the Netherlands, ou_persistent22              
3Faculty of Social and Behavioural Sciences, Utrecht University, the Netherlands, ou_persistent22              
4Section Clinical Neuropsychology, VU University Amsterdam, the Netherlands, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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 Abstract: 7 Tesla (7T) magnetic resonance imaging holds great promise for improved visualization of the human brain for clinical purposes. To assess whether 7T is superior regarding localization procedures of small brain structures, we compared manual parcellations of the red nucleus, subthalamic nucleus, substantia nigra, globus pallidus interna and externa. These parcellations were created on a commonly used clinical anisotropic clinical 3T with an optimized isotropic (o)3T and standard 7T scan. The clinical 3T MRI scans did not allow delineation of an anatomically plausible structure due to its limited spatial resolution. o3T and 7T parcellations were directly compared. We found that 7T outperformed the o3T MRI as reflected by higher Dice scores, which were used as a measurement of interrater agreement for manual parcellations on quantitative susceptibility maps. This increase in agreement was associated with higher contrast to noise ratios for smaller structures, but not for the larger globus pallidus segments. Additionally, control-analyses were performed to account for potential biases in manual parcellations by assessing semi-automatic parcellations. These results showed a higher consistency for structure volumes for 7T compared to optimized 3T which illustrates the importance of the use of isotropic voxels for 3D visualization of the surgical target area. Together these results indicate that 7T outperforms c3T as well as o3T given the constraints of a clinical setting.

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Language(s): eng - English
 Dates: 2020-06-292020-11-062020-11-24
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0236208
Other: eCollection 2020
PMID: 33232325
PMC: PMC7685480
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Title: PLoS One
Source Genre: Journal
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Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 15 (11) Sequence Number: e0236208 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850