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  Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss

Signorelli, C. M., Uhrig, L., Kringelbach, M., Jarraya, B., & Deco, G. (2021). Hierarchical disruption in the cortex of anesthetized monkeys as a new signature of consciousness loss. NeuroImage, 227: 117618. doi:10.1016/j.neuroimage.2020.117618.

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 Creators:
Signorelli, Camilo Miguel1, Author
Uhrig, Lynn1, Author
Kringelbach, Morten1, Author
Jarraya, Bechir1, Author
Deco, Gustavo2, Author              
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1External Organizations, ou_persistent22              
2Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Anesthesia; Integration; Ignition; Measures of Consciousness; IIT; GNW
 Abstract: Anesthesia induces a reconfiguration of the repertoire of functional brain states leading to a high function-structure similarity. However, it is unclear how these functional changes lead to loss of consciousness. Here we suggest that the mechanism of conscious access is related to a general dynamical rearrangement of the intrinsic hierarchical organization of the cortex. To measure cortical hierarchy, we applied the Intrinsic Ignition analysis to resting-state fMRI data acquired in awake and anesthetized macaques. Our results reveal the existence of spatial and temporal hierarchical differences of neural activity within the macaque cortex, with a strong modulation by the depth of anesthesia and the employed anesthetic agent. Higher values of Intrinsic Ignition correspond to rich and flexible brain dynamics whereas lower values correspond to poor and rigid, structurally driven brain dynamics. Moreover, spatial and temporal hierarchical dimensions are disrupted in a different manner, involving different hierarchical brain networks. All together suggest that disruption of brain hierarchy is a new signature of consciousness loss.

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Language(s): eng - English
 Dates: 2020-11-142020-06-042020-12-012020-12-082021-02-15
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.117618
Other: online ahead of print
PMID: 33307225
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 227 Sequence Number: 117618 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166