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  Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex

Noei, S., Zouridis, I., Logothetis, N., Panzeri, S., & Totah, N. (2020). Noradrenergic locus coeruleus ensembles fire at distinct times to evoke different cortical states in rat prefrontal cortex. In J. Pezaris, & N. Hatsopoulos (Eds.), AREADNE 2020: Research in Encoding and Decoding of Neural Ensembles (pp. 94). Cambridge, MA, USA: The AREADNE Foundation.

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 Creators:
Noei, S, Author
Zouridis, I1, 2, Author              
Logothetis, NK1, 2, Author              
Panzeri, S, Author              
Totah, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The Locus Coeruleus (LC), a noradrenergic brain stem nucleus projecting throughout the forebrain, is thought to act as an undifferentiated state controller across all forebrain targets because LC neurons spike synchronously [1, 2]. However, recent work demonstrated ensembles in the LC and therefore made targeted neuromodulation a possibility [3]. This recent study used graph theory to reveal a static snapshot of LC ensembles. In order to now demonstrate that LC ensembles cause targeted neuromodulation, it is necessary to resolve LC ensemble dynamics over time in relation to ongoing cortical states.

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 Dates: 2020-06
 Publication Status: Published online
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Title: AREADNE 2020: Research in Encoding and Decoding of Neural Ensembles
Place of Event: Santorini, Greece
Start-/End Date: 2020-06-16 - 2020-06-20

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Title: AREADNE 2020: Research in Encoding and Decoding of Neural Ensembles
Source Genre: Proceedings
 Creator(s):
Pezaris, JS, Editor
Hatsopoulos, NG, Editor
Affiliations:
-
Publ. Info: Cambridge, MA, USA : The AREADNE Foundation
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 94 Identifier: ISSN: 2155-3203