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  Current Understanding of the Mechanism of Water Oxidation in Photosystem II and Its Relation to XFEL Data

Cox, N., Pantazis, D. A., & Lubitz, W. (2020). Current Understanding of the Mechanism of Water Oxidation in Photosystem II and Its Relation to XFEL Data. Annual Review of Biochemistry, 89, 795-820. doi:10.1146/annurev-biochem-011520-104801.

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 Creators:
Cox, Nicholas 1, Author
Pantazis, Dimitrios A.2, Author              
Lubitz, Wolfgang3, Author              
Affiliations:
1Research School of Chemistry, The Australian National University, Canberra ACT 2601, Australia, ou_persistent22              
2Research Group Pantazis, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2541711              
3Research Department Lubitz, Max Planck Institute for Chemical Energy Conversion, Max Planck Society, ou_3023873              

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Free keywords: oxygen-evolving complex in PS II; spectroscopy; X-ray crystallography; X-ray free-electron laser; XFEL; quantum chemical calculations; water oxidation mechanism
 Abstract: The investigation of water oxidation in photosynthesis has remained a central topic in biochemical research for the last few decades due to the importance of this catalytic process for technological applications. Significant progress has been made following the 2011 report of a high-resolution X-ray crystallographic structure resolving the site of catalysis, a protein-bound Mn4CaOx complex, which passes through ≥5 intermediate states in the water-splitting cycle. Spectroscopic techniques complemented by quantum chemical calculations aided in understanding the electronic structure of the cofactor in all (detectable) states of the enzymatic process. Together with isotope labeling, these techniques also revealed the binding of the two substrate water molecules to the cluster. These results are described in the context of recent progress using X-ray crystallography with free-electron lasers on these intermediates. The data are instrumental for developing a model for the biological water oxidation cycle.

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Language(s): eng - English
 Dates: 2020-03-242020-06-01
 Publication Status: Published in print
 Pages: 26
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Annual Review of Biochemistry
  Abbreviation : Annu. Rev. Biochem.
Source Genre: Journal
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Publ. Info: Palo Alto, Calif. : Stanford University Press
Pages: - Volume / Issue: 89 Sequence Number: - Start / End Page: 795 - 820 Identifier: ISSN: 0066-4154
CoNE: https://pure.mpg.de/cone/journals/resource/954925458038