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Free keywords:
μ-Conotoxin GIIIA; Geographutoxin; NMR, 2D; Distance geometry; Peptide synthesis; Canus geographus
Abstract:
We have investigated the structure of μ-conotoxin GIIIA by 2D-NMR methods. The assignment of 1H NMR spectra and a quantitative analysis of NOE and J-coupling data are presented. These results were used for the calculation of secondary structure elements of μ-conotoxin GIIIA. Distance geometry calculations were carried out to define the global folding of the peptide.