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  Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin

Bischoff, P., Kornhuber, M., Dunst, S., Zell, J., Fauler, B., Mielke, T., et al. (2020). Estrogens Determine Adherens Junction Organization and E-Cadherin Clustering in Breast Cancer Cells via Amphiregulin. iScience, 23(11): 101683. doi:10.1016/j.isci.2020.101683.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-A892-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-6ED8-A
Genre: Journal Article

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PIIS2589004220308750.pdf (Publisher version), 8MB
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c) 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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http://creativecommons.org/licenses/by-nc-nd/4.0/

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 Creators:
Bischoff, Philip1, Author
Kornhuber, Marja1, Author
Dunst, Sebastian1, Author
Zell, Jakob1, Author
Fauler, Beatrix1, Author
Mielke, Thorsten1, Author
Taubenberger, Anna V.1, Author
Guck, Jochen2, 3, 4, Author           
Oelgeschlaeger, Michael1, Author
Schoenfelder, Gilbert1, Author
Affiliations:
1external, ou_persistent22              
2Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              
3Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
4Friedrich-Alexander Universität Erlangen-Nürnberg, ou_persistent22              

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 Abstract: Estrogens play an important role in the development and progression of human cancers, particularly in breast cancer. Breast cancer progression depends on the malignant destabilization of adherens junctions (AJs) and disruption of tissue integrity. We found that estrogen receptor alpha (ER alpha) inhibition led to a striking spatial reorganization of AJs and microclustering of E-Cadherin (E-Cad) in the cell membrane of breast cancer cells. This resulted in increased stability of AJs and cell stiffness and a reduction of cell motility. These effects were actomyosindependent and reversible by estrogens. Detailed investigations showed that the ERa target gene and epidermal growth factor receptor (EGFR) ligand Amphiregulin (AREG) essentially regulates AJ reorganization and E-Cad microclustering. Our results not only describe a biological mechanism for the organization of AJs and the modulation of mechanical properties of cells but also provide a new perspective on how estrogens and anti-estrogens might influence the formation of breast tumors.

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Language(s): eng - English
 Dates: 2020-11-20
 Publication Status: Published online
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 Identifiers: DOI: 10.1016/j.isci.2020.101683
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Title: iScience
Source Genre: Journal
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Publ. Info: Cell Press
Pages: - Volume / Issue: 23 (11) Sequence Number: 101683 Start / End Page: - Identifier: -