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  Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

Guidi, M., Moon, S.-Y., Anghileri, L., Cambié, D., Seeberger, P. H., & Gilmore, K. (2021). Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines. Reaction Chemistry & Engineering, 6(2), 220-224. doi:10.1039/D0RE00445F.

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 Creators:
Guidi, Mara1, Author              
Moon, Soo-Yeon1, Author              
Anghileri, Lucia2, Author              
Cambié, Dario2, Author              
Seeberger, Peter H.3, Author              
Gilmore, Kerry1, Author              
Affiliations:
1Kerry Gilmore, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863304              
2Dario Cambié, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_3256668              
3Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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 Abstract: Current drug production in batch cannot adapt rapidly to market demands,} evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand production of active pharmaceutical ingredients (APIs). Here{,} we reveal a new concept to develop and produce APIs{,} where an automated synthesizer that works with discrete volumes of solutions is employed at the discovery stage to identify the optimal synthetic route and conditions before a commercially available continuous flow system is used for scale-up. This concept is illustrated by the synthesis of nifedipine and paracetamol{,} in short supply in Germany during the COVID-19 pandemic{, and the local anesthetic lidocaine.

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Language(s): eng - English
 Dates: 2020-01-052021
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1039/D0RE00445F
BibTex Citekey: D0RE00445F
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Title: Reaction Chemistry & Engineering
Source Genre: Journal
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Publ. Info: Cambridge : Royal Society of Chemistry
Pages: - Volume / Issue: 6 (2) Sequence Number: - Start / End Page: 220 - 224 Identifier: ISSN: 2058-9883