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  Optically transparent vertical silicon nanowire arrays for live-cell imaging

Elnathan, R., Holle, A. W., Young, J. L., George, M., Heifler, O., Goychuk, A., et al. (2021). Optically transparent vertical silicon nanowire arrays for live-cell imaging. Journal of Nanobiotechnology, 1-11. doi:10.21203/rs.3.rs-138271/v1.

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 Creators:
Elnathan, Roey, Author
Holle, Andrew W.1, Author              
Young, Jennifer L.1, Author              
George, Marina, Author
Heifler, Omri, Author
Goychuk, Andriy, Author
Frey, Erwin, Author
Kemkemer, Ralf, Author
Spatz, Joachim P.1, Author              
Kosloff, Alon, Author
Patolsky, Fernando, Author
Voelcker, Nico, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: nanowires, cell–material interface, live-cell phase-contrast imaging, silicon, glass substrate
 Abstract: Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong potential for ground-breaking advances, particularly in cellular nanobiotechnology and mechanobiology. However, the opaque nature of many nanostructured surfaces makes non-destructive, live-cell characterization of cellular behavior on vertically aligned nanostructures challenging to observe. Here, a new nanofabrication route is proposed that enables harvesting of vertically aligned silicon (Si) nanowires and their subsequent transfer onto an optically transparent substrate, with high efficiency and without artefacts. We demonstrate the potential of this route for efficient live-cell phase contrast imaging and subsequent characterization of cells growing on vertically aligned Si nanowires. This approach provides the first opportunity to understand dynamic cellular responses to a cell-nanowire interface, and thus has the potential to inform the design of future nanoscale cellular manipulation technologies.

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Language(s): eng - English
 Dates: 2021-01-032021-01-05
 Publication Status: Published online
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.21203/rs.3.rs-138271/v1
 Degree: -

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Title: Journal of Nanobiotechnology
Source Genre: Journal
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Publ. Info: London : BioMed Central Ltd
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 1 - 11 Identifier: ISSN: 1477-3155
CoNE: https://pure.mpg.de/cone/journals/resource/1477-3155