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  Evidence of fNIRS-based prefrontal cortex hypoactivity in obesity and binge-eating disorder

Rösch, S., Schmidt, R., Lührs, M., Ehlis, A.-C., Hesse, S., & Hilbert, A. (2020). Evidence of fNIRS-based prefrontal cortex hypoactivity in obesity and binge-eating disorder. Brain Sciences, 11(1): 19. doi:10.3390/brainsci11010019.

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 Creators:
Rösch, Sarah1, 2, Author           
Schmidt, Ricarda1, Author
Lührs, Michael3, 4, Author
Ehlis, Ann-Christine5, Author
Hesse, Swen6, Author
Hilbert, Anja1, Author
Affiliations:
1Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
2International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2616696              
3Brain Innovation B.V., Maastricht, the Netherlands, ou_persistent22              
4Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
5Department for Psychiatry and Psychotherapy, Eberhard Karls University Tübingen, Germany, ou_persistent22              
6Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              

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Free keywords: Obesity; Binge-eating disorder; fNIRS; Emotional dysregulation; Prefrontal cortex; Impulsivity
 Abstract: Obesity (OB) and associated binge-eating disorder (BED) show increased impulsivity and emotional dysregulation. Albeit well-established in neuropsychiatric research, functional near-infrared spectroscopy (fNIRS) has rarely been used to study OB and BED. Here, we investigated fNIRS-based food-specific brain signalling, its association with impulsivity and emotional dysregulation, and the temporal variability in individuals with OB with and without BED compared to an age- and sex-stratified normal weight (NW) group. Prefrontal cortex (PFC) responses were recorded in individuals with OB (n = 15), OB + BED (n = 13), and NW (n = 12) in a passive viewing and a response inhibition task. Impulsivity and emotional dysregulation were self-reported; anthropometrics were objectively measured. The OB and NW groups were measured twice 7 days apart. Relative to the NW group, the OB and OB + BED groups showed PFC hyporesponsivity across tasks, whereas there were few significant differences between the OB and OB + BED groups. Greater levels of impulsivity were significantly associated with stronger PFC responses, while more emotional dysregulation was significantly associated with lower PFC responses. Temporal differences were found in the left orbitofrontal cortex responses, yet in opposite directions in the OB and NW groups. This study demonstrated diminished fNIRS-based PFC responses across OB phenotypes relative to a NW group. The association between impulsivity, emotional dysregulation, and PFC hypoactivity supports the assumption that BED constitutes a specific OB phenotype.

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Language(s): eng - English
 Dates: 2020-12-162020-12-012020-12-222020-12-26
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/brainsci11010019
PMID: 33375315
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Title: Brain Sciences
Source Genre: Journal
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Publ. Info: Basel, Switzerland : Multidisciplinary Digital Publishing Institute (MDPI)
Pages: - Volume / Issue: 11 (1) Sequence Number: 19 Start / End Page: - Identifier: ISSN: 2076-3425
CoNE: https://pure.mpg.de/cone/journals/resource/2076-3425