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  Fast retrograde access to projection neuron circuits underlying vocal learning in songbirds

Düring, D. N., Dittrich, F., Diales da Rocha, M., Tachibana, R. O., Mori, C., Okanoya, K., et al. (2020). Fast retrograde access to projection neuron circuits underlying vocal learning in songbirds. Cell Reports, 33(6): 108364. doi:10.1016/j.celrep.2020.108364.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-ABD7-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-ABD8-5
Genre: Journal Article
Subtitle : Resource

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1-s2.0-S221112472031353X-main.pdf (Publisher version), 6MB
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 Creators:
Düring, Daniel Normen1, Author              
Dittrich, Falk1, Author              
Diales da Rocha, Mariana1, Author              
Tachibana, Ryosuke O.1, Author
Mori, Chihiro1, Author
Okanoya, Kazuo1, Author
Boehringer, Roman1, Author
Ehret, Benjamin1, Author
Grewe, Benjamin F.1, Author
Gerber, Stefan1, Author
Ma, Shouwen 1, Author
Rauch, Melanie1, Author
Paterna, Jean-Charles1, Author
Kasper, Robert2, Author              
Gahr, Manfred1, Author              
Hahnloser, Richard H.R.1, Author
Affiliations:
1External Organizations, ou_persistent22              
2MPI of Neurobiology, Max Planck Society, ou_1110547              

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 Abstract: Understanding the structure and function of neural circuits underlying speech and language is a vital step toward better treatments for diseases of these systems. Songbirds, among the few animal orders that share with humans the ability to learn vocalizations from a conspecific, have provided many insights into the neural mechanisms of vocal development. However, research into vocal learning circuits has been hindered by a lack of tools for rapid genetic targeting of specific neuron populations to meet the quick pace of developmental learning. Here, we present a viral tool that enables fast and efficient retrograde access to projection neuron populations. In zebra finches, Bengalese finches, canaries, and mice, we demonstrate fast retrograde labeling of cortical or dopaminergic neurons. We further demonstrate the suitability of our construct for detailed morphological analysis, for in vivo imaging of calcium activity, and for multi-color brainbow labeling.

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 Dates: 2020-11-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.celrep.2020.108364
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Title: Cell Reports
Source Genre: Journal
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Publ. Info: Maryland Heights, MO : Cell Press
Pages: - Volume / Issue: 33 (6) Sequence Number: 108364 Start / End Page: - Identifier: ISSN: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247