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  Complex multicomponent patterns rendered on a 3D DNA-barrel pegboard

Wickham, S. F. J., Auer, A., Min, J., Ponnuswamy, N., Woehrstein, J. B., Schueder, F., et al. (2020). Complex multicomponent patterns rendered on a 3D DNA-barrel pegboard. Nature Communications, 11(1): 5768. doi:10.1038/s41467-020-18910-x.

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 Creators:
Wickham, Shelley F. J.1, Author
Auer, Alexander2, Author              
Min, Jianghong1, Author
Ponnuswamy, Nandhini1, Author
Woehrstein, Johannes B.2, Author              
Schueder, Florian2, Author              
Strauss, Maximilian T.2, Author              
Schnitzbauer, Joerg2, Author              
Nathwani, Bhavik1, Author
Zhao, Zhao1, Author
Perrault, Steven D.1, Author
Hahn, Jaeseung1, Author
Lee, Seungwoo1, Author
Bastings, Maartje M.1, Author
Helmig, Sarah W.1, Author
Kodal, Anne Louise1, Author
Yin, Peng1, Author
Jungmann, Ralf2, Author              
Shih, William M.1, Author
Affiliations:
1external, ou_persistent22              
2Jungmann, Ralf / Molecular Imaging and Bionanotechnology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2149679              

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Free keywords: SUPERRESOLUTION MICROSCOPY; FOLDING DNA; NANOSTRUCTURES; SHAPES; ENHANCEMENT; PRECISION; NANOROBOTScience & Technology - Other Topics;
 Abstract: DNA origami, in which a long scaffold strand is assembled with a many short staple strands into parallel arrays of double helices, has proven a powerful method for custom nanofabrication. However, currently the design and optimization of custom 3D DNA-origami shapes is a barrier to rapid application to new areas. Here we introduce a modular barrel architecture, and demonstrate hierarchical assembly of a 100 megadalton DNA-origami barrel of similar to 90nm diameter and similar to 250nm height, that provides a rhombic-lattice canvas of a thousand pixels each, with pitch of similar to 8nm, on its inner and outer surfaces. Complex patterns rendered on these surfaces were resolved using up to twelve rounds of Exchange-PAINT super-resolution microscopy. We envision these structures as versatile nanoscale pegboards for applications requiring complex 3D arrangements of matter, which will serve to promote rapid uptake of this technology in diverse fields beyond specialist groups working in DNA nanotechnology.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 10
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 Table of Contents: -
 Rev. Type: Peer
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Project name : DFG JU 2957/1-1
Grant ID : -
Funding program : Emmy Noether Program
Funding organization : German Research Foundation
Project name : SFB1032 (project A11)
Grant ID : -
Funding program : -
Funding organization : German Research Foundation
Project name : MolMap
Grant ID : 680241
Funding program : ERC Starting Grant
Funding organization : European Research Council

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 11 (1) Sequence Number: 5768 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723